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Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women.

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dc.contributor.authorSharma, D.K.
dc.contributor.authorAnderson, P.H.
dc.contributor.authorMorris, H.A.
dc.contributor.authorClifton, P.M.
dc.date.issued2020
dc.description.abstractThe protective effect of obesity on bone health has been challenged by studies that link visceral adiposity to poor bone microarchitecture in young obese men and women. In postmenopausal women, the role of visceral adipose tissue (VAT) on bone turnover markers (BTMs) has not been investigated. The aim was to investigate the impact of VAT on BTMs, total bone mineral density (BMD), vitamin D metabolites and parathyroid levels (1-84 PTH) levels in postmenopausal women. A total of 76 lean and overweight women (without osteoporosis) underwent VAT measurements by dual-energy X-ray absorptiometry (iDXA). Blood samples were analyzed for serum C-terminal telopeptide of type 1 collagen (CTX-1), osteocalcin, bone-specific alkaline phosphatase (bone ALP), 1-84 PTH and vitamin D (25 hydroxyvitamin D, 25(OH)D) levels. VAT volumes ranged from 91 to 3392 cm3 and body mass index (BMI) ranged from 18.3 to 53.9 kg/m2. Women in the highest VAT quartile had significantly lower CTX-1, 25(OH)D, osteocalcin and the highest BMD (p < 0.05, for all). While VAT positively associated with BMD, after controlling for BMI, VAT was a negative predictor of BMD (β = 0.368, p < 0.05). VAT was an independent negative predictor of CTX-1 (β = -0.263, p < 0.05) and osteocalcin levels (β = -0.277, p < 0.05). Among all measures of adiposity, VAT was the strongest independent determinant of BMD and BTMs. In clinical settings, VAT, and not BMI, may be a sensitive predictor of bone health in obese women.
dc.identifier.citationInternational Journal of Environmental Research and Public Health, 2020; 17(11):1-12
dc.identifier.doi10.3390/ijerph17113996
dc.identifier.issn1661-7827
dc.identifier.issn1660-4601
dc.identifier.orcidAnderson, P.H. [0000-0002-8685-3252]
dc.identifier.orcidMorris, H.A. [0000-0002-2745-3750]
dc.identifier.orcidClifton, P.M. [0000-0002-6411-626X]
dc.identifier.urihttps://hdl.handle.net/11541.2/143262
dc.language.isoen
dc.publisherM D P I AG
dc.rightsCopyright 2020 the Authors. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.3390/ijerph17113996
dc.subjectbone turnover
dc.subjectCTX-1
dc.subjectobesity
dc.subjectparathyroid hormone
dc.subjectpostmenopausal women
dc.subjectvisceral fat
dc.subjectvitamin D
dc.titleVisceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women.
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12200922890001831 13200922880001831 ijerph-17-03996-v2.pdf
ror.mmsid9916418510901831

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