The clinical significance of gastrointestinal changes with aging

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dc.contributor.authorBhutto, A.
dc.contributor.authorMorley, J.
dc.date.issued2008
dc.description.abstract<h4>Purpose of review</h4>With the graying of the world's population, there is an increased interest in the physiological effects of aging. This review examines the physiological changes of the gut with aging and their clinical significance.<h4>Recent findings</h4>Changes with aging in the gastrointestinal tract are variable, but in some cases they are responsible for a variety of symptoms. Thus, alterations in taste and smell, gastric motility, intestinal overgrowth and changes in gastrointestinal hormone release are the basis of the physiological anorexia of aging. Alterations in swallowing lead to silent aspiration. Changes in gastric emptying play a role in postprandial hypotension. Changes in gastrointestinal function can lead to constipation and fecal incontinence. Weakening of the colonic muscular wall produces diverticula. Achlorhydria is associated with malabsorption of some forms of iron and calcium. Vitamin D malabsorption aggravates the hypovitaminosis D that is so common in older persons. Changes in probiotics can lead to diarrhea and altered immune system. In the liver, aging is associated with delayed drug metabolism.<h4>Summary</h4>Changes in the physiology of the gut play a role in the anorexia of aging, aspiration pneumonia, postprandial hypotension, constipation and fecal incontinence.
dc.description.statementofresponsibilityBhutto, Asif; Morley, John E
dc.identifier.citationCurrent Opinion in Clinical Nutrition and Metabolic Care, 2008; 11(5):651-660
dc.identifier.doi10.1097/MCO.0b013e32830b5d37
dc.identifier.issn1363-1950
dc.identifier.issn1535-3885
dc.identifier.orcidMorley, J. [0000-0001-6444-2965]
dc.identifier.urihttp://hdl.handle.net/2440/52538
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.source.urihttps://doi.org/10.1097/mco.0b013e32830b5d37
dc.subjectGastrointestinal Tract
dc.subjectEnteric Nervous System
dc.subjectHumans
dc.subjectAnorexia
dc.subjectSensation
dc.subjectAging
dc.subjectDeglutition
dc.subjectGastrointestinal Motility
dc.subjectIntestinal Absorption
dc.subjectProbiotics
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.titleThe clinical significance of gastrointestinal changes with aging
dc.typeJournal article
pubs.publication-statusPublished

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