Review: Placental adaptations to the presence of maternal asthma during pregnancy
Date
2017
Authors
Meakin, A.S.
Saif, Z.
Jones, A.R.
Aviles, P.F.V.
Clifton, V.L.
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Advisors
Journal Title
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Volume Title
Type:
Journal article
Citation
Placenta, 2017; 54
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Conference Name
Abstract
Asthma is a highly prevalent chronic medical condition affecting an estimated 12% of pregnant, women each year, with prevalence of asthma greatest (up to 16%) among the socially disadvantaged. Maternal asthma is associated with significant perinatal morbidity and mortality including preterm births, neonatal hospitalisations and low birthweight outcomes each year. We have identified that the placenta adapts to the presence of chronic, maternal asthma during pregnancy in a sex specific manner that may confer sex differences in fetal outcome. The male fetus was at greater risk of a poor outcome than a female fetus in the presence of maternal asthma and an acute inflammatory event such as an asthma exacerbation. This review will examine the role of sex specific differences in placental function on fetal growth and survival.
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Description
Link to a related website: https://unpaywall.org/10.1016/j.placenta.2017.01.123, Open Access via Unpaywall
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Copyright 2017 Elsevier