Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo
Date
2008
Authors
Kerfoot, S.
Andonegui, G.
Bonder, C.S.
Liu, L.
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Journal article
Citation
American Journal of Physiology. Heart and Circulatory Physiology, 2008; 294(6):2524-2534
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Abstract
Stromal cell-derived factor-1 (SDF-1; CXCL12), a CXC chemokine, has been found to be involved in inflammation models in vivo and in cell adhesion, migration, and chemotaxis in vitro. This study aimed to determine whether exogenous SDF-1 induces leukocyte recruitment in mice. We conclude that the exogenous SDF-1 enhances leukocyte-endothelial cell interactions and induces modest and endothelial P-selectin-dependent leukocyte recruitment.
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Copyright 2008 The American Physiological Society