Current studentsExisting staffContact us
 

Discovery of Aspergillus frankstonensis sp. nov. during environmental sampling for animal and human fungal pathogens

Simple item page
dc.contributor.authorTalbott, J.J.
dc.contributor.authorHoubraken, J.
dc.contributor.authorFrisvad, J.C.
dc.contributor.authorSamson, R.A.
dc.contributor.authorKidd, S.
dc.contributor.authorPitt, J.
dc.contributor.authorLindsay, S.
dc.contributor.authorBeatty, J.A.
dc.contributor.authorBarrs, V.R.
dc.contributor.editorKniemeyer, O.
dc.date.issued2017
dc.description.abstractInvasive fungal infections, IFI, due to species in Aspergillus section Fumigati, ASF, including the Aspergillus viridinutans species complex, AVSC, are increasingly reported in humans and cats. The risk of exposure to these medically important fungi in Australia is unknown. Air and soil was sampled from the domiciles of pet cats diagnosed with these IFI and from a nature reserve in Frankston, Victoria, where Aspergillus viridinutans sensu stricto was discovered in, . Of, ASF species isolated, were A. fumigatus sensu stricto, were AVSC, A. felis-clade and A. frankstonensis sp. nov., and, were other species, . Seven pathogenic ASF species known to cause disease in humans and animals, A. felis-clade, A. fischeri, A. thermomutatus, A. lentulus, A. laciniosus A. fumisynnematus, A. hiratsukae, comprised, of isolates overall. AVSC species were only isolated from Frankston soil where they were abundant, suggesting a particular ecological niche. Phylogenetic, morphological and metabolomic analyses of these isolates identified a new species, A. frankstonensis that is phylogenetically distinct from other AVSC species, heterothallic and produces a unique array of extrolites, including the UV spectrum characterized compounds DOLD, RAIMO and CALBO. Shared morphological and physiological characteristics with other AVSC species include slow sporulation, optimal growth at, ÊC, no growth at, ÊC, and viriditoxin production. Overall, the risk of environmental exposure to pathogenic species in ASF in Australia appears to be high, but there was no evidence of direct environmental exposure to AVSC species in areas where humans and cats cohabitate.
dc.description.statementofresponsibilityJessica J. Talbot, Jos Houbraken, Jens C. Frisvad, Robert A. Samson, Sarah E. Kidd, John Pitt, Sue Lindsay, Julia A. Beatty, Vanessa R. Barrs
dc.identifier.citationPLoS ONE, 2017; 12(8):e0181660-1-e0181660-17
dc.identifier.doi10.1371/journal.pone.0181660
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.orcidKidd, S. [0000-0002-5957-4178]
dc.identifier.urihttp://hdl.handle.net/2440/111628
dc.language.isoen
dc.publisherPublic Library of Science (PLoS)
dc.rightsCopyright: © 2017 Talbot et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttps://doi.org/10.1371/journal.pone.0181660
dc.subjectAnimals
dc.subjectCats
dc.subjectHumans
dc.subjectAspergillus
dc.subjectAspergillosis
dc.subjectNaphthols
dc.subjectDNA, Fungal
dc.subjectAntifungal Agents
dc.subjectMicrobial Sensitivity Tests
dc.subjectSequence Analysis, DNA
dc.subjectSoil Microbiology
dc.subjectEnvironmental Exposure
dc.subjectEnvironmental Monitoring
dc.subjectPhylogeny
dc.subjectBase Sequence
dc.subjectAustralia
dc.subjectInvasive Fungal Infections
dc.titleDiscovery of Aspergillus frankstonensis sp. nov. during environmental sampling for animal and human fungal pathogens
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_111628.pdf
Size:
10.27 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Molecular and Biomedical Science publications