Two isomeric a and b aspartyl dodecapeptides and their cyclic amino succinyl analogues from the Australian Green Tree Frog Litoria gilleni
Date
1995
Authors
Waugh, R.
Steinborner, S.
Bowie, J.
Wallace, J.
Tyler, M.
Hu, P.
Gross, M.
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Advisors
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Volume Title
Type:
Journal article
Citation
Australian Journal of Chemistry: an international journal for chemical science, 1995; 48(12):1981-1987
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Abstract
<jats:p>Three related peptides, caeridins 1.1-1.3, have been isolated from the green tree frog Litoria gilleni. Caeridins 1.1 and 1.2 are dodecapeptides differing only in having α and β Asp at residue 4 [viz. Gly Leu Leu Asp Gly Leu Leu Gly Thr Leu Gly Leu (NH2)]. Caeridin 1.3 is the corresponding cyclic amino succinyl derivative derived formally by cyclization of Asp(4) and Gly (5). Hydrolysis of caeridin 1.3 yields caeridin 1.1 and 1.2 in the ratio 3:1. This constitutes a rare case of the isolation of three such related peptides from a natural system. </jats:p>