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A Single Faecal Microbiota Transplantation Altered the Microbiota of Weaned Pigs.

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dc.contributor.authorNowland, T.L.
dc.contributor.authorTorok, V.A.
dc.contributor.authorLow, W.Y.
dc.contributor.authorPlush, K.J.
dc.contributor.authorBarton, M.D.
dc.contributor.authorKirkwood, R.N.
dc.date.issued2020
dc.description.abstractWeaning is a stressful time for piglets, often leading to weight loss and is associated with increased morbidity and mortality. A leading cause for these post-weaning problems is enteric dysbiosis and methods to improve piglet health at this crucial developmental stage are needed. This study aimed to determine whether an enteric dysbiosis caused by weaning could be corrected via a faecal microbiota transplantation (FMT) from healthy piglets from a previous wean. Two or four focal piglets per litter were assigned to one of two treatments; FMT two days post weaning (n = 21; FMT) or a control which received saline two days post weaning (n = 21; CON). FMT consisted of homogenised donor faeces administered orally at 3 mL/kg. Weaning occurred at 18 days of age and weights and faecal samples were collected on days 18, 20, 24 and 35. 16S rRNA amplicon analysis was used to assess the faecal microbiota of piglets. FMT increased Shannon's diversity post weaning (p < 0.001) and reduced the scratch score observed at 24 days of age (p < 0.001). The bacterial populations significantly differed in composition at each taxonomic level. In FMT pigs, significant increases in potentially pathogenic Escherichia coli were observed. However, increases in beneficial bacteria Lactobacillus mucosae and genera Fibrobacteres and Bacteroidetes were also observed in FMT treated animals. To our knowledge, this is the first study to observe a significant effect on piglet faecal microbiota following a single FMT administered post weaning. Therefore, FMT post weaning can potentially alleviate enteric dysbiosis.
dc.identifier.citationLife, 2020; 10(9)
dc.identifier.doi10.3390/life10090203
dc.identifier.issn2075-1729
dc.identifier.issn2075-1729
dc.identifier.orcidNowland, T.L. [0000-0001-8812-5948]
dc.identifier.orcidLow, W.Y. [0000-0002-0749-765X]
dc.identifier.orcidKirkwood, R.N. [0000-0002-3294-8301]
dc.identifier.urihttps://hdl.handle.net/11541.2/145275
dc.language.isoen
dc.publisherMDPIAG
dc.relation.fundingAustralian Pork Limited
dc.rightsCopyright 2020 The author(s). Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (https://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.3390/life10090203
dc.subjectenteric dysbiosis
dc.subjectenteric microbiota
dc.subjectmicrobiota transplantation
dc.subjectpigs
dc.subjectweaning
dc.titleA Single Faecal Microbiota Transplantation Altered the Microbiota of Weaned Pigs.
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12207866400001831 13207876570001831 life-10-00203-v2.pdf
ror.mmsid9916446206901831

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