CD4⁺ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4⁺ T cells

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dc.contributor.authorFernandez, S.
dc.contributor.authorTanaskovic, S.
dc.contributor.authorHelbig, K.
dc.contributor.authorRajasuriar, R.
dc.contributor.authorKramski, M.
dc.contributor.authorMurray, J.
dc.contributor.authorBeard, M.
dc.contributor.authorPurcell, D.
dc.contributor.authorLewin, S.
dc.contributor.authorPrice, P.
dc.contributor.authorFrench, M.
dc.date.issued2011
dc.description.abstractMost patients with human immunodeficiency virus (HIV) who remain CD4⁺ T-cell deficient on antiretroviral therapy (ART) exhibit marked immune activation. As CD4⁺ T-cell activation may be mediated by microbial translocation or interferon-alpha (IFN-α), we examined these factors in HIV patients with good or poor CD4⁺ T-cell recovery on long-term ART. Messenger RNA levels for 3 interferon-stimulated genes were increased in CD4⁺ T cells of patients with poor CD4⁺ T-cell recovery, whereas levels in patients with good recovery did not differ from those in healthy controls. Poor CD4⁺ T-cell recovery was also associated with CD4⁺ T-cell expression of markers of activation, senescence, and apoptosis, and with increased serum levels of the lipopolysaccharide receptor and soluble CD14, but these were not significantly correlated with expression of the interferon-stimulated genes. Therefore, CD4⁺ T-cell recovery may be adversely affected by the effects of IFN-α, which may be amenable to therapeutic intervention.
dc.description.statementofresponsibilitySonia Fernandez, Sara Tanaskovic, Karla Helbig, Reena Rajasuriar, Marit Kramski, John M. Murray, Michael Beard, Damian Purcell, Sharon R. Lewin, Patricia Price and Martyn A. French
dc.identifier.citationJournal of Infectious Diseases, 2011; 204(12):1927-1935
dc.identifier.doi10.1093/infdis/jir659
dc.identifier.issn0022-1899
dc.identifier.issn1537-6613
dc.identifier.orcidBeard, M. [0000-0002-4106-1016]
dc.identifier.urihttp://hdl.handle.net/2440/69156
dc.language.isoen
dc.publisherUniv Chicago Press
dc.rights© The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
dc.source.urihttps://doi.org/10.1093/infdis/jir659
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectCD8-Positive T-Lymphocytes
dc.subjectCells, Cultured
dc.subjectHumans
dc.subjectHIV Infections
dc.subjectLipopolysaccharides
dc.subjectAdaptor Proteins, Signal Transducing
dc.subjectRNA-Binding Proteins
dc.subjectInterferon-alpha
dc.subjectTranscription Factors
dc.subjectRNA, Messenger
dc.subjectHLA-DR Antigens
dc.subjectAnti-Retroviral Agents
dc.subjectCD4 Lymphocyte Count
dc.subjectCross-Sectional Studies
dc.subjectLymphocyte Activation
dc.subjectApoptosis
dc.subjectGene Expression
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectLipopolysaccharide Receptors
dc.subjectCD57 Antigens
dc.subjectfas Receptor
dc.titleCD4⁺ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4⁺ T cells
dc.title.alternativeCD4(+) T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4(+) T cells
dc.typeJournal article
pubs.publication-statusPublished

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