Motion capture quantification of user Variation in topical microparticle application
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Date
2020
Authors
Snoswell, A.J.
Yamada, M.
Kirby, G.T.S.
Singh, S.P.N.
Prow, T.W.
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Journal article
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Frontiers in Pharmacology, 2020; 11(1343):1-8
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Abstract
Motion capture has the potential to shed light on topical drug delivery application. This approach holds promise both as a training tool, and for the development of skin technology, but first, this approach requires validation. Elongated microparticles (EMP) are a physical delivery enhancement technology that relies on a user working in the microparticles using a textured applicator. We used this approach to test the hypothesis that motion capture data can be used to characterize the topical application process. Motion capture was used to record participants while applying a mixture of EMP and sodium fluorescein to ex-vivo porcine skin samples. Treated skin was assessed using reflectance confocal and fluorescence microscopy. Image analysis was used to quantify the microparticle density and the presence of a fluorescent drug surrogate, sodium fluorescein. A strong correlation was present between applicator motion and microparticle and drug delivery profiles. There were quantitative and qualitative differences in the intra- and inter- user application methods that went beyond the level of training. Frequency and velocity of the applicator motion were key factors that correlated with EMP density. Our quantitative analysis of an experimental dermatological device supports the hypothesis that self-application may benefit from some form of digital monitoring or training with feedback. Our conclusion is that the integration of motion capture into experimental dermatological research offers an improved and quantifiable perspective that could be broadly useful with respect to topical applications, and with respect to the instruction provided to patients and clinicians.
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Copyright 2020 The author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice (https://creativecommons.org/licenses/by/4.0/)