Natural History of Oral HPV Infection among Indigenous South Australians

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dc.contributor.authorJu, X.
dc.contributor.authorSethi, S.
dc.contributor.authorAntonsson, A.
dc.contributor.authorHedges, J.
dc.contributor.authorCanfell, K.
dc.contributor.authorSmith, M.
dc.contributor.authorGarvey, G.
dc.contributor.authorLogan, R.M.
dc.contributor.authorJamieson, L.M.
dc.date.issued2023
dc.description.abstractThis study aims to describe the natural history of and identify the risk factors associated with oral human papillomavirus (HPV) infections in an Australian Indigenous cohort. A longitudinal cohort study design, with baseline (2018), 12-month, and 24-month data obtained from Indigenous Australians aged 18+ years in South Australia, was performed. Face-to-face interviews were conducted, and saliva samples for HPV testing were collected at each time point. Basic descriptive analyses were conducted to calculate prevalence, incidence, persistence, clearance, and incidence proportions of any HPV infection. Multivariable logistic regression analyses with adjusted prevalence ratios (PRs) were conducted to identify risk factors associated with oral HPV infection. Among 993 participants with valid saliva samples, 44 HPV types were identified. The prevalence of infection with any oral HPV infection was 51.3%, high-risk HPV was 11%, and types implicated in Heck’s disease (HPV 13 or 32) was 37.4%. The incidence, persistence, and clearance of any and high-risk HPV infections were 30.7%, 11.8% and 33.3% vs. 9.3%, 2.8%, and 9%, respectively. Our findings indicate that the prevalence, incidence, and persistence of oral HPV infection in a large sample of Indigenous Australians were high, and clearance was low. Oral sex behaviours and recreational drug use were risk factors associated with incident high-risk HPV infection.
dc.description.statementofresponsibilityXiangqun Ju, Sneha Sethi, Annika Antonsson, Joanne Hedges, Karen Canfell, Megan Smith, Gail Garvey, Richard M. Logan, and Lisa M. Jamieson
dc.identifier.citationViruses, 2023; 15(7):1573-1573
dc.identifier.doi10.3390/v15071573
dc.identifier.issn1999-4915
dc.identifier.issn1999-4915
dc.identifier.orcidJu, X. [0000-0003-4759-3918]
dc.identifier.orcidSethi, S. [0000-0002-3571-5298]
dc.identifier.orcidHedges, J. [0000-0002-2413-5992]
dc.identifier.orcidLogan, R.M. [0000-0002-9331-1814]
dc.identifier.orcidJamieson, L.M. [0000-0001-9839-9280]
dc.identifier.urihttps://hdl.handle.net/2440/139142
dc.language.isoen
dc.publisherMDPI AG
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1120215
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1102587
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1159491
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1176651
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.source.urihttps://doi.org/10.3390/v15071573
dc.subjecthuman papilloma viruses (HPV); oropharyngeal cancer; indigenous; incidence; persistence
dc.subject.meshHumans
dc.subject.meshPapillomaviridae
dc.subject.meshPapillomavirus Infections
dc.subject.meshMouth Diseases
dc.subject.meshPrevalence
dc.subject.meshRisk Factors
dc.subject.meshLongitudinal Studies
dc.subject.meshAustralia
dc.subject.meshSouth Australia
dc.titleNatural History of Oral HPV Infection among Indigenous South Australians
dc.typeJournal article
pubs.publication-statusPublished online

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