Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

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dc.contributor.authorGraff, M.
dc.contributor.authorScott, R.
dc.contributor.authorJustice, A.
dc.contributor.authorYoung, K.
dc.contributor.authorFeitosa, M.
dc.contributor.authorBarata, L.
dc.contributor.authorWinkler, T.
dc.contributor.authorChu, A.
dc.contributor.authorMahajan, A.
dc.contributor.authorHadley, D.
dc.contributor.authorXue, L.
dc.contributor.authorWorkalemahu, T.
dc.contributor.authorHeard-Costa, N.
dc.contributor.authorden Hoed, M.
dc.contributor.authorAhluwalia, T.
dc.contributor.authorQi, Q.
dc.contributor.authorNgwa, J.
dc.contributor.authorRenström, F.
dc.contributor.authorQuaye, L.
dc.contributor.authorEicher, J.
dc.contributor.authoret al.
dc.contributor.editorEdwards, T.
dc.date.issued2017
dc.description.abstractPhysical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
dc.description.statementofresponsibilityMariaelisa Graff ... Lyle J. Palmer ... et al.
dc.identifier.citationPLoS Genetics, 2017; 13(4):e1006528-1-e1006528-26
dc.identifier.doi10.1371/journal.pgen.1006528
dc.identifier.issn1553-7390
dc.identifier.issn1553-7404
dc.identifier.urihttp://hdl.handle.net/2440/107074
dc.language.isoen
dc.publisherPublic Library of Science
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dc.rightsThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
dc.source.urihttps://doi.org/10.1371/journal.pgen.1006528
dc.subjectBody mass index; genome-wide association study
dc.titleGenome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
dc.typeJournal article
pubs.publication-statusPublished

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