Modeling oxygen transport in surgical tissue transfer

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dc.contributor.authorMatzavinos, A.
dc.contributor.authorKao, C.
dc.contributor.authorGreen, J.
dc.contributor.authorSutradhar, A.
dc.contributor.authorMiller, M.
dc.contributor.authorFriedman, A.
dc.date.issued2009
dc.description.abstractReconstructive microsurgery is a clinical technique used to transfer large amounts of a patient's tissue from one location used to another in order to restore physical deformities caused by trauma, tumors, or congenital abnormalities. The trend in this field is to transfer tissue using increasingly smaller blood vessels, which decreases problems associated with tissue harvest but increases the possibility that blood supply to the transferred tissue may not be adequate for healing. It would thus be helpful to surgeons to understand the relationship between the tissue volume and blood vessel diameter to ensure success in these operations. As a first step towards addressing this question, we present a simple mathematical model that might be used to predict successful tissue transfer based on blood vessel diameter, tissue volume, and oxygen delivery.
dc.description.statementofresponsibilityAnastasios Matzavinos, Chiu-Yen Kao, J. Edward F. Green, Alok Sutradhar, Michael Miller and Avner Friedman
dc.identifier.citationProceedings of the National Academy of Sciences of USA, 2009; 106(29):12091-12096
dc.identifier.doi10.1073/pnas.0905037106
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.orcidGreen, J. [0000-0001-5061-9563]
dc.identifier.urihttp://hdl.handle.net/2440/69921
dc.language.isoen
dc.publisherNatl Acad Sciences
dc.rights© Authors
dc.source.urihttps://doi.org/10.1073/pnas.0905037106
dc.subjectreconstructive surgery
dc.subjectsurgical flap
dc.subjectischemia
dc.subjectporous media
dc.subjectPDE model
dc.titleModeling oxygen transport in surgical tissue transfer
dc.typeJournal article
pubs.publication-statusPublished

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