A patient-derived explant (PDE) model of hormone-dependent cancer

Simple item page
dc.contributor.authorCentenera, M.M.
dc.contributor.authorHickey, T.E.
dc.contributor.authorJindal, S.
dc.contributor.authorRyan, N.K.
dc.contributor.authorRavindranathan, P.
dc.contributor.authorMohammed, H.
dc.contributor.authorRobinson, J.L.
dc.contributor.authorSchiewer, M.J.
dc.contributor.authorMa, S.
dc.contributor.authorKapur, P.
dc.contributor.authorSutherland, P.D.
dc.contributor.authorHoffmann, C.E.
dc.contributor.authorRoehrborn, C.G.
dc.contributor.authorGomella, L.G.
dc.contributor.authorCarroll, J.S.
dc.contributor.authorBirrell, S.N.
dc.contributor.authorKnudsen, K.E.
dc.contributor.authorRaj, G.V.
dc.contributor.authorButler, L.M.
dc.contributor.authorTilley, W.D.
dc.date.issued2018
dc.description.abstractBreast and prostate cancer research to date has largely been predicated on the use of cell lines in vitro or in vivo. These limitations have led to the development of more clinically relevant models, such as organoids or murine xenografts that utilize patient-derived material; however, issues related to low take rate, long duration of establishment, and the associated costs constrain use of these models. This study demonstrates that ex vivo culture of freshly resected breast and prostate tumor specimens obtained from surgery, termed patient-derived explants (PDEs), provides a high-throughput and cost-effective model that retains the native tissue architecture, microenvironment, cell viability, and key oncogenic drivers. The PDE model provides a unique approach for direct evaluation of drug responses on an individual patient's tumor, which is amenable to analysis using contemporary genomic technologies. The ability to rapidly evaluate drug efficacy in patient-derived material has high potential to facilitate implementation of personalized medicine approaches.
dc.description.statementofresponsibilityMargaret M. Centenera, Theresa E. Hickey, Shalini Jindal, Natalie K. Ryan, Preethi Ravindranathan, Hisham Mohammed, Jessica L. Robinson, Matthew J. Schiewer, Shihong Ma, Payal Kapur, Peter D. Sutherland, Clive E. Hoffmann, Claus G. Roehrborn, Leonard G. Gomella, Jason S. Carroll, Stephen N. Birrell, Karen E. Knudsen, Ganesh V. Raj, Lisa M. Butler, Wayne D. Tilley
dc.identifier.citationMolecular Oncology, 2018; 12(9):1608-1622
dc.identifier.doi10.1002/1878-0261.12354
dc.identifier.issn1574-7891
dc.identifier.issn1878-0261
dc.identifier.orcidCentenera, M.M. [0000-0002-2206-0632]
dc.identifier.orcidHickey, T.E. [0000-0002-2752-730X]
dc.identifier.orcidBirrell, S.N. [0000-0002-1023-413X]
dc.identifier.orcidButler, L.M. [0000-0003-2698-3220]
dc.identifier.orcidTilley, W.D. [0000-0003-1893-2626]
dc.identifier.urihttp://hdl.handle.net/2440/115468
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627185
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1008349
dc.relation.grantARC
dc.rights© 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1002/1878-0261.12354
dc.subjectex vivo culture
dc.subjectpatient-derived explant
dc.subjectpreclinical tumor model
dc.titleA patient-derived explant (PDE) model of hormone-dependent cancer
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_115468.pdf
Size:
1.44 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Medicine publications