A platypus’ eye view of the mammalian genome

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dc.contributor.authorGrutzner, F.
dc.contributor.authorGraves, J.
dc.date.issued2004
dc.descriptionCopyright © 2004 Elsevier
dc.description.abstractThe genome of monotremes, like the animals themselves, is unique and strange. The importance of monotremes to genomics depends on their position as the earliest offshoot of the mammalian lineage. Although there has been controversy in the literature over the phylogenetic position of monotremes, this traditional interpretation is now confirmed by recent sequence comparisons. Characterizing the monotreme genome will therefore be important for studying the evolution and organization of the mammalian genome, and the proposal to sequence the platypus genome has been received enthusiastically by the genomics community. Recent investigations of X-chromosome inactivation, genomic imprinting and sex chromosome evolution provide good examples of the power of the monotreme genome to inform us about mammalian genome organization and evolution.
dc.description.statementofresponsibilityFrank Grützner and Jennifer A Marshall Graves
dc.identifier.citationCurrent Opinion in Genetics and Development, 2004; 14(6):642-649
dc.identifier.doi10.1016/j.gde.2004.09.006
dc.identifier.issn0959-437X
dc.identifier.issn1879-0380
dc.identifier.orcidGrutzner, F. [0000-0002-3088-7314]
dc.identifier.urihttp://hdl.handle.net/2440/34731
dc.language.isoen
dc.publisherCurrent Biology Ltd
dc.source.urihttp://www.elsevier.com/wps/locate/issn/0959437X
dc.subjectSex Chromosomes
dc.subjectAnimals
dc.subjectPlatypus
dc.subjectGenomic Imprinting
dc.subjectGenome
dc.subjectBiological Evolution
dc.titleA platypus’ eye view of the mammalian genome
dc.typeJournal article
pubs.publication-statusPublished

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