360His polymorphism of the apolipoproteinA-IV gene and plasma lipid response to energy restricted diets in overweight subjects

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dc.contributor.authorHeilbronn, L.
dc.contributor.authorNoakes, M.
dc.contributor.authorCoates, A.
dc.contributor.authorKind, K.
dc.contributor.authorClifton, P.
dc.date.issued2000
dc.description.abstractObesity is commonly associated with high rates of cardiovascular disease (CVD). Weight loss in obese subjects reduces risk factors for CVD but this response is not uniform. Genetic factors could be involved in this variability. The 360His polymorphism of apolipoproteinA-IV (apoA-IV) influences the lipid response to fat intake, but it is unclear whether this polymorphism could contribute to lipid variability during weight loss. Therefore, we assessed the effects of an energy restricted diet (6.3 MJ) for 12 weeks on weight loss and plasma lipids according to apoA-IV genotype in 186 overweight/obese subjects (BMI mean 33+/-4.3, range 25.0-48.0 kg/m(2)). The frequency of the 360His allele was 0.083. Energy restriction for 12 weeks resulted in an average weight loss of 8. 25+/-0.28 kg. HDL-C increased 5.4% in subjects with the apoA-IV-1/1 genotype with weight loss compared to a 2.6% decrease in apoA-IV-1/2 subjects (P=0.035). This was more apparent when only the subjects with type 2 diabetes (n=57) were analyzed (P=0.003). ApoA-IV genotype was not related to change in total cholesterol, LDL-C or triglyceride concentrations. Therefore, weight loss as a treatment to reduce CVD risk factors may be more effective in subjects with the apoA-IV-1/1 variant as compared to those with the apoA-IV-1/2 variant, especially in subjects with type 2 diabetes.
dc.identifier.citationAtherosclerosis, 2000; 150(1):187-192
dc.identifier.doi10.1016/S0021-9150(99)00367-6
dc.identifier.issn0021-9150
dc.identifier.issn1879-1484
dc.identifier.orcidHeilbronn, L. [0000-0003-2106-7303]
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]
dc.identifier.urihttp://hdl.handle.net/2440/11730
dc.language.isoen
dc.publisherElsevier Sci Ireland Ltd
dc.source.urihttps://doi.org/10.1016/s0021-9150(99)00367-6
dc.subjectHumans
dc.subjectDiabetes Mellitus
dc.subjectObesity
dc.subjectWeight Loss
dc.subjectCholesterol
dc.subjectLipids
dc.subjectTriglycerides
dc.subjectApolipoproteins A
dc.subjectDiet, Reducing
dc.subjectEnergy Intake
dc.subjectPolymorphism, Genetic
dc.subjectAlleles
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectCholesterol, LDL
dc.subjectCholesterol, HDL
dc.title360His polymorphism of the apolipoproteinA-IV gene and plasma lipid response to energy restricted diets in overweight subjects
dc.typeJournal article
pubs.publication-statusPublished

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