Development in children with achondroplasia: a prospective clinical cohort study

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dc.contributor.authorIreland, P.
dc.contributor.authorDonaghey, S.
dc.contributor.authorMcGill, J.
dc.contributor.authorZankl, A.
dc.contributor.authorWare, R.
dc.contributor.authorPacey, V.
dc.contributor.authorAult, J.
dc.contributor.authorSavarirayan, R.
dc.contributor.authorSillence, D.
dc.contributor.authorThompson, E.
dc.contributor.authorTownshend, S.
dc.contributor.authorJohnston, L.
dc.date.issued2012
dc.description.abstractAIM: Achondroplasia is characterized by delays in the development of communication andmotor skills. While previously reported developmental profiles exist across gross motor, fine motor, feeding, and communication skills, there has been no prospective study of development across multiple areas simultaneously. METHOD: This Australasian population-based study utilized a prospective questionnaire to quantify developmental data for skills in children born from 2000 to 2009. Forty-eight families from Australia and New Zealand were asked to report every 3 months on their child’s attainment of 41 milestones. Results include reference to previously available prospective information. RESULTS: Information from questionnaires was used to develop an achondroplasia-specific developmental recording form. The 25th, 50th, 75th, and 90th centiles were plotted to offer clear guidelines for development across gross motor, finemotor, feeding, and communication skills in children with achondroplasia. INTERPRETATIONS: Consistent with results from previous research, children with achondroplasia are delayed in development of gross motor and ambulatory skills. Young children with achondroplasia demonstrate a number of uniquemovement strategies that appear compensatory for the biomechanical changes.While delays were seen in development of later communication items, there were fewer delays seen across development of early communication, finemotor, and feeding skills.
dc.description.statementofresponsibilityPenelope J. Ireland, Samantha Donaghey, James McGill, Andreas Zankl, Robert S. Ware, Verity Pacey, Jenny Ault, Ravi Savarirayan, David Sillence, Elizabeth Thompson, Sharron Townshend and Leanne M. Johnston
dc.identifier.citationDevelopmental Medicine and Child Neurology, 2012; 54(6):532-537
dc.identifier.doi10.1111/j.1469-8749.2012.04234.x
dc.identifier.issn0012-1622
dc.identifier.issn1469-8749
dc.identifier.urihttp://hdl.handle.net/2440/72121
dc.language.isoen
dc.publisherCambridge Univ Press
dc.rights© The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press
dc.source.urihttps://doi.org/10.1111/j.1469-8749.2012.04234.x
dc.subjectHumans
dc.subjectAchondroplasia
dc.subjectDisability Evaluation
dc.subjectSeverity of Illness Index
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectDevelopmental Disabilities
dc.subjectMovement
dc.subjectChild, Preschool
dc.subjectFamily Health
dc.subjectCommunity Health Planning
dc.subjectAustralia
dc.subjectNew Zealand
dc.subjectFemale
dc.subjectMale
dc.subjectSurveys and Questionnaires
dc.titleDevelopment in children with achondroplasia: a prospective clinical cohort study
dc.typeJournal article
pubs.publication-statusPublished

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