Insights into the invasive diagnostic challenges of coronary artery vasospasm - A systematic review

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dc.contributor.authorRehan, R.
dc.contributor.authorBeltrame, J.
dc.contributor.authorYong, A.
dc.date.issued2024
dc.descriptionAvailable online 3 August 2023
dc.description.abstractCoronary provocation testing is an essential diagnostic procedure when evaluating vasospastic angina. Invasive methods using acetylcholine or ergonovine are considered the current gold standard. Despite efforts from global cardiovascular institutions, current protocols vary in dosage, administration time, and procedural approach. In addition, concerns over the specificity of findings and potential complications have limited routine uptake of this procedure in clinical practice. This systematic review evaluates current diagnostic protocols, focusing on invasive provocation testing. We included studies using intracoronary provocation testing with acetylcholine or ergonovine for the assessment of coronary artery vasospasm that detailed specific elements of the procedure (dosage, administration time, etc.) and included ≥50 patients. A total of 28 articles met strict inclusion criteria. Our review highlights the heterogeneity between current diagnostic protocols for invasive provocation testing. We believe standardization of a diagnostic protocol will encourage both current and future cardiologists to incorporate such procedures in the evaluation of variant angina.
dc.description.statementofresponsibilityRajan Rehan, John Beltrame, Andy Yong
dc.identifier.citationJournal of Cardiology, 2024; 83(1):8-16
dc.identifier.doi10.1016/j.jjcc.2023.07.020
dc.identifier.issn0914-5087
dc.identifier.issn1876-4738
dc.identifier.orcidBeltrame, J. [0000-0002-4294-6510]
dc.identifier.urihttps://hdl.handle.net/2440/139499
dc.language.isoen
dc.publisherElsevier
dc.relation.grantNHMRC
dc.rights© 2023 Japanese College of Cardiology. Published by Elsevier Ltd. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.source.urihttps://doi.org/10.1016/j.jjcc.2023.07.020
dc.subjectAcetylcholine
dc.subjectCoronary artery vasospasm
dc.subjectErgonovine
dc.subjectIntracoronary provocation testing
dc.subjectVasospastic angina
dc.titleInsights into the invasive diagnostic challenges of coronary artery vasospasm - A systematic review
dc.typeJournal article
pubs.publication-statusPublished

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