Elucidating the role of regulatory B cells in early pregnancy /
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(Published version)
Date
2020
Authors
Guzman-Genuino, Ruth Marian
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Type:
thesis
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Abstract
Pregnancy is a unique predicament that requires a shift in form and function among immune cells. In this thesis, we focused on the role of regulatory B cells (Bregs) in the establishment of a healthy pregnancy. We demonstrated that B cells acquire a regulatory phenotype by virtue of their IL-10 production and high expression of co-stimulatory molecules at the peri-implantation period. Moreover, we showed that fetal trophoblast cells can educate B cells to acquire regulatory properties capable of modulating inflammation to allow for successful embryo implantation. Lastly, we evaluated the possibility of harnessing these Bregs as a therapeutic tool to address immune-based pregnancy pathologies. Collectively, our findings support the emerging insight that Bregs are actively engaged in the regulatory immune network necessary to achieve fetal tolerance and therefore a successful pregnancy.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences.
Dissertation Note
Thesis (PhD(Medical Science))--University of South Australia, 2020.
Provenance
Copyright 2020 Ruth Marian Guzman-Genuino.
Description
1 ethesis (xx, 160 pages) :
illustrations (mostly colour)
Includes bibliographical references (pages 135-159)
illustrations (mostly colour)
Includes bibliographical references (pages 135-159)
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