Tumour-suppressive activity of the growth arrest-specific gene, GAS1 / by Andreas Avdokiou.
Date
1997
Authors
Evdokiou, Andreas
Editors
Advisors
Journal Title
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Type:
Thesis
Citation
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Abstract
The results presented in this thesis establish the growth-suppressive activity of the human GAS1 gene and provide the first direct evidence that GAS1 can inhibit the growth of tumours. In addition, this study demonstrates that the antiproliferative effect of GAS1 are mediated by a p53 dependent pathway and that functional inactivation of p53 by either mutation and/or overexpression of the MDM2 oncogene product inhibits the GAS1 mediated growth-suppression.
School/Discipline
Dept. of Physiology
Dissertation Note
Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 1997?
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This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals
Description
Bibliography: leaves 170-196.
xix, 199 leaves, [84] leaves of plates : ill. (some col.) ; 30 cm.
xix, 199 leaves, [84] leaves of plates : ill. (some col.) ; 30 cm.