Structured regression analyses of life course processes: An example exploring how maternal depression in early childhood affects children's subsequent internalizing behavior

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dc.contributor.authorGiles, L.
dc.contributor.authorDavies, M.
dc.contributor.authorWhitrow, M.
dc.contributor.authorRumbold, A.
dc.contributor.authorLynch, J.
dc.contributor.authorSawyer, M.
dc.contributor.authorMoore, V.
dc.date.issued2011
dc.description.abstractPURPOSE: One of the specific aims of life course epidemiology is to assess the explanatory utility of three general hypotheses, namely the critical period hypothesis, the accumulation of risk hypothesis, and the effect modification hypothesis. METHODS: A structured regression approach to this problem is illustrated with data from an ongoing longitudinal study of children and their families established in Adelaide in 1998-2000. A series of nested models that correspond to the alternative life course hypotheses were fit in an investigation of the effects of maternal depressive states in early childhood on internalizing child behavior at 9.5 years. Both linear and logistic regression models were considered. RESULTS: The structured regression framework showed the accumulation hypothesis was most plausible for these data. The analyses also provided some evidence of a critical period for the effect of maternal depressive status around child age 2 years on internalizing behavior at 9.5 years. CONCLUSIONS: The findings of this study suggest that comparing a suite of nested models to a full model can be useful in attempting to disentangle life course processes.
dc.description.statementofresponsibilityLynne Giles, Michael Davies, Melissa Whitrow, Alice Rumbold, John Lynch, Michael Sawyer, and Vivienne Moore
dc.identifier.citationAnnals of Epidemiology, 2011; 21(9):654-659
dc.identifier.doi10.1016/j.annepidem.2011.04.002
dc.identifier.issn1047-2797
dc.identifier.issn1873-2585
dc.identifier.orcidGiles, L. [0000-0001-9054-9088]
dc.identifier.orcidDavies, M. [0000-0002-5809-7541] [0000-0003-1526-0801]
dc.identifier.orcidRumbold, A. [0000-0002-4453-9425]
dc.identifier.orcidLynch, J. [0000-0003-2781-7902]
dc.identifier.orcidSawyer, M. [0000-0002-7834-0561]
dc.identifier.orcidMoore, V. [0000-0001-9505-6450]
dc.identifier.urihttp://hdl.handle.net/2440/68148
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/465437
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/465455
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627033
dc.rightsCopyright © 2011 Elsevier Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.annepidem.2011.04.002
dc.subjectCritical Period
dc.subjectGeneralized Linear Models
dc.subjectIntergenerational Health
dc.subjectLongitudinal Study
dc.titleStructured regression analyses of life course processes: An example exploring how maternal depression in early childhood affects children's subsequent internalizing behavior
dc.typeJournal article
pubs.publication-statusPublished

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