Sentinal node biopsy and large (>3cm) breast cancer

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dc.contributor.authorBeumer, J.
dc.contributor.authorGill, P.
dc.contributor.authorCampbell, I.
dc.contributor.authorWetzig, N.
dc.contributor.authorUng, O.
dc.contributor.authorFarshid, G.
dc.contributor.authorUren, R.
dc.contributor.authorStockler, M.
dc.contributor.authorGebski, V.
dc.date.issued2013
dc.description.abstractBACKGROUND Sentinel node biopsy is an accurate method for staging the axilla in early (small) breast cancers. However, data for the role of this technique for large breast cancers remain limited. METHOD From the Royal Adelaide Hospital Sentinel Node database and the SNAC trial database, 100 subjects were identified with clinically node negative, large (≥3 cm) primary breast cancer who had undergone sentinel node biopsy and immediate axillary clearance. The pathology results from the sentinel node and axillary specimens were analysed. RESULTS Average tumour size was 3.91 cm (range 3–10 cm) and 65 of 100 cases had metastatic disease in the axillary nodes. A sentinel node was successfully identified in 93 out of 100 cases with an average of 1.75 sentinel nodes sampled. Sixty-two per cent (58 out of 93) were sentinel node positive and 43% (43 out of 100) had a positive non-sentinel node. The false negative rate following successful sentinel node identification was 4.9% (3 out of 61). CONCLUSION Sentinel node biopsy was an accurate tool for staging the axilla with a false negative rate comparable to that seen in small tumours. However, given the increased incidence of metastases with larger cancers, further prospective investigation is warranted.
dc.description.statementofresponsibilityJesse D. Beumer, Grantley Gill, Ian Campbell, Neil Wetzig, Owen Ung, Gelareh Farshid, Roger Uren, Martin Stockler and Val Gebski
dc.identifier.citationANZ Journal of Surgery, 2013; 84(3):117-120
dc.identifier.doi10.1111/ans.12139
dc.identifier.issn1445-1433
dc.identifier.issn1445-2197
dc.identifier.orcidGill, P. [0000-0001-7310-2970]
dc.identifier.orcidFarshid, G. [0000-0002-2056-0561]
dc.identifier.urihttp://hdl.handle.net/2440/82404
dc.language.isoen
dc.publisherBlackwell Science Asia
dc.rights© 2013 University of Adelaide.
dc.source.urihttps://doi.org/10.1111/ans.12139
dc.subjectBreast neoplasm
dc.subjectcarcinoma ductal breast
dc.subjectsentinel lymph node biopsy
dc.titleSentinal node biopsy and large (>3cm) breast cancer
dc.typeJournal article
pubs.publication-statusPublished

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