New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry

Simple item page
dc.contributor.authorMaclean, M.
dc.contributor.authorBrinkworth, C.
dc.contributor.authorBilusich, D.
dc.contributor.authorBowie, J.
dc.contributor.authorDoyle, J.
dc.contributor.authorLlewellyn, L.
dc.contributor.authorTyler, M.
dc.date.issued2006
dc.descriptionCopyright © 2006 Elsevier Ltd All rights reserved.
dc.description.abstractThe skin secretion of the Dainty Green Tree Frog Litoria gracilenta contains 16 peptides, which protect the animal from predators, both large and small. A combination of negative and positive ion electrospray mass spectrometry together with Lys-C enzymic digest and Edman sequencing identifies three new wide-spectrum caerin 1 antibiotics, namely Caerin 1.17 [GLFSVLGSVAKHLLPHVAPIIAEKL-NH2], Caerin 1.18 [GLFSVLGSVAKHLLPHVVPVIAEKL-NH2], and Caerin 1.19 [GLFKVLGSVAKHLLPHVAPIIAEKL-NH2], and a narrow spectrum antibiotic Caerin 3.5 [GLWEKVKEKANELVSGIVEGVK-NH2].
dc.description.statementofresponsibilityMicheal J. Maclean, Craig S. Brinkworth, Daniel Bilusich, John H. Bowie, Jason R. Doyle, Lyndon E. Llewellyn and Michael J. Tyler
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/259/description#description
dc.identifier.citationToxicon, 2006; 47(6):664-675
dc.identifier.doi10.1016/j.toxicon.2006.01.019
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.urihttp://hdl.handle.net/2440/23548
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.source.urihttps://doi.org/10.1016/j.toxicon.2006.01.019
dc.subjectDainty Green Tree Frog
dc.subjectskin secretion
dc.subjectcaerin antibiotic peptides
dc.titleNew caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Chemistry publications