An analysis of the interactions between individual comorbidities and their treatments - implications for guidelines and polypharmacy
Date
2010
Authors
Fitzgerald, S.
Bean, N.
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Journal article
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Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues, 2010; 11(7):475-484
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Stephen P. Fitzgerald and Nigel G. Bean
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Abstract
<h4>Background</h4>With aging there is an increase in frailty and chronic disease leading to a potential increase in medication use. Most clinical trials have excluded old, frail individuals and have failed to take into account the effects of outcome interaction.<h4>Methods and results</h4>In this article we provide a mathematical model demonstrating that comorbidities, including old age, interact with therapies, reducing their effectiveness.<h4>Conclusion</h4>These findings question the validity of single disease guidelines in old persons or in persons with multiple chronic diseases.
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Copyright © 2010 American Medical Directors Association Published by Elsevier Inc.