Steroid hormone and epidermal growth factor receptors in meningiomas

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dc.contributor.authorHorsfall, D.J.
dc.contributor.authorGoldsmith, K.G.
dc.contributor.authorRicciardelli, C.
dc.contributor.authorSkinner, J.M.
dc.contributor.authorTilley, W.D.
dc.contributor.authorMarshall, V.R.
dc.date.issued1989
dc.description.abstractA prospective study of steroid hormone and epidermal growth factor receptor expression in 57 meningiomas is presented. Scatchard analysis of radioligand binding identified 20% of meningiomas as expressing classical oestrogen receptors (ER) at levels below that normally accepted for positivity, the remainder being negative. ER could not be visualized in any meningioma using immunocytochemistry. Alternatively, 74% of meningiomas demonstrated the presence of progesterone receptors (PR) by Scatchard analysis, the specificity of which could not be attributed to glucocorticoid or androgen receptors. Confirmation of classical PR presence was determined by immunocytochemical staining. The presence of epidermal growth factor receptor (EGFR) was demonstrated in 100% of meningiomas using immunocytochemical staining. These data are reviewed in the context of previously reported results and are discussed in relation to the potential for medical therapy as an adjunct to surgery.
dc.description.statementofresponsibilityDavid J. Horsfall, Kimberly G. Goldsmith, Carmela Ricciardelli, John M. Skinner, Wayne D. Tilley, Villis R. Marshall
dc.identifier.citationANZ Journal of Surgery, 1989; 59(11):881-888
dc.identifier.doi10.1111/j.1445-2197.1989.tb07033.x
dc.identifier.issn0004-8682
dc.identifier.issn1445-2197
dc.identifier.orcidRicciardelli, C. [0000-0001-7415-1854]
dc.identifier.orcidTilley, W.D. [0000-0003-1893-2626]
dc.identifier.urihttp://hdl.handle.net/2440/119757
dc.language.isoen
dc.publisherWiley Online Library
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1111/j.1445-2197.1989.tb07033.x
dc.subjectEpidermal growth factor receptor; immunocytocbemistry; meningioma; oestrogen receptor; progesterane receptor; scatchard analysis
dc.titleSteroid hormone and epidermal growth factor receptors in meningiomas
dc.typeJournal article
pubs.publication-statusPublished

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