Effectiveness and safety as outcome measures in reproductive medicine

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dc.contributor.authorBraakhekke, M.
dc.contributor.authorKamphuis, E.I.
dc.contributor.authorMol, F.
dc.contributor.authorNorman, R.J.
dc.contributor.authorBhattacharya, S.
dc.contributor.authorVan Der Veen, F.
dc.contributor.authorMol, B.W.J.
dc.date.issued2015
dc.description.abstractThe aim of reproductive medicine is to help couples with an unfulfilled child wish to have a child by offering them the best treatment option. The choice of treatment reflects effectiveness and safety. While effectiveness refers to the extent to which a treatment increases the chance of a couple in having a baby, safety relates to adverse effects associated with such a treatment. In an attempt to integrate effectiveness and safety, healthy singleton live birth (at term) has been suggested as the ideal outcome measure for evaluative research in reproductive medicine. Although intuitively desirable, this proposal overlooks the fact that assessment of effectiveness and safety in this context cannot be measured as a single outcome. In this paper, we explain why effectiveness and safety outcomes in reproductive medicine should be assessed independently, and later synthesized to inform clinical decision-making.
dc.description.statementofresponsibilityM. Braakhekke, E.I. Kamphuis, F. Mol, R.J. Norman, S. Bhattacharya, F. van der Veen, and B.W.J. Mol
dc.identifier.citationHuman Reproduction, 2015; 30(10):2249-2251
dc.identifier.doi10.1093/humrep/dev201
dc.identifier.issn0268-1161
dc.identifier.issn1460-2350
dc.identifier.orcidNorman, R.J. [0000-0002-3118-3896]
dc.identifier.orcidMol, B.W.J. [0000-0001-6887-0262] [0000-0001-8337-550X]
dc.identifier.urihttp://hdl.handle.net/2440/95715
dc.language.isoen
dc.publisherOXFORD UNIV PRESS
dc.rights© The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
dc.source.urihttps://doi.org/10.1093/humrep/dev201
dc.subjectEffectiveness; safety; outcome measures; reproductive medicine
dc.titleEffectiveness and safety as outcome measures in reproductive medicine
dc.typeJournal article
pubs.publication-statusPublished

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