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Integrating International Consensus Guidelines for Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) into everyday practice

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dc.contributor.authorSandhu, G.
dc.contributor.authorAdattini, J.
dc.contributor.authorArmstrong Gordon, E.
dc.contributor.authorO'Neill, N.
dc.contributor.authorBoddy, A.V.
dc.contributor.authorWard, R.L.
dc.date.issued2025
dc.descriptionData source: supplementary data, https://ars.els-cdn.com/content/image/1-s2.0-S2589537025000938-mmc1.docx
dc.description.abstractPart 2 of the International Consensus Guideline on Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) offers drug-specific consensus recommendations based on both evidence and practical experience. These recommendations build upon the kidney function assessment and classification guidelines established in Part 1 of ADDIKD. Here we illustrate how dosing recommendations differ between ADDIKD and existing guidance for four commonly used drugs: methotrexate, cisplatin, carboplatin and nivolumab. We then describe how the recommendations can be distilled into practice points for methotrexate and cisplatin. While ADDIKD is a significant improvement from previous guidelines, adoption of this new guideline requires further endorsement from key external stakeholders,‘change championing’ by clinicians locally and encouraging its integration into existing reference sources, clinical trial protocols and electronic prescribing systems.
dc.identifier.citationEClinicalMedicine, 2025; 82(103161):1-11
dc.identifier.doi10.1016/j.eclinm.2025.103161
dc.identifier.issn2589-5370
dc.identifier.issn2589-5370
dc.identifier.urihttps://hdl.handle.net/11541.2/42727
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright 2025 the Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1016/j.eclinm.2025.103161
dc.subjectchemotherapy
dc.subjectdrug dosing
dc.subjectkidney dysfunction
dc.subjectrenal
dc.subjectoncology
dc.subjecthaematology
dc.subjectpharmacokinetics
dc.titleIntegrating International Consensus Guidelines for Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) into everyday practice
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916965046601831

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