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Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents

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dc.contributor.authorSivakumar, B.
dc.contributor.authorAswathy, R.G.
dc.contributor.authorRomero Aburto, R.
dc.contributor.authorMitcham, T.
dc.contributor.authorMitchel, K.A.
dc.contributor.authorNagaoka, Y.
dc.contributor.authorBouchard, R.R.
dc.contributor.authorAjayan, P.M.
dc.contributor.authorMaekawa, T.
dc.contributor.authorSakthikumar, D.N.
dc.date.issued2017
dc.description.abstractWe have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics. The hyperthermic ability of these nanocomposites was mediated by SPIONs upon NIR-laser irradiation. In vitro cytotoxicity was shown by curcumin-loaded nanoparticles as well as the photothermal ablation of cancer cells mediated by the drug-encapsulated nanocomposite demonstrated the potential therapeutic effect of the nanocomposite. In short, we portray the aptamer-conjugated nanocomposite as a multimodal material capable of serving as a contrast agent for MR, photoacoustic and optical imaging. Furthermore, the nanocomposite functions as a targetable drug nanocarrier and a NIR-laser inducible hyperthermic material that is capable of ablating PANC-1 and MIA PaCa-2 cancer cell lines.
dc.identifier.citationBiomaterials Science, 2017; 5(3):432-443
dc.identifier.doi10.1039/c6bm00621c
dc.identifier.issn2047-4830
dc.identifier.issn2047-4849
dc.identifier.urihttps://hdl.handle.net/11541.2/125327
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.fundingMinistry of Education, Culture, Sports, Science and Technology S1101017
dc.relation.fundingNational Cancer Institute CA16672
dc.rightsCopyright 2017 The Royal Society of Chemistry
dc.source.urihttps://doi.org/10.1039/c6bm00621c
dc.subjectablation
dc.subjectcancer cells
dc.subjectmultimodal imaging
dc.subjectnanoparticles
dc.titleHighly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916119998101831

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