A mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation

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dc.contributor.authorLudbrook, G.
dc.contributor.authorMacintyre, P.
dc.contributor.authorDouglas, H.
dc.contributor.authorOng, J.
dc.contributor.authorUpton, R.
dc.date.issued2001
dc.descriptionThe definitive version is available at www.blackwell-synergy.com
dc.description.abstractPharmacokinetic modelling of estimated central nervous system concentrations was used to devise the optimal mixture of morphine and alfentanil for the treatment of postoperative pain. Modelling revealed that an intravenous opioid pain protocol using an alfentanil−morphine mixture in the proportions 0.75 : 10 mg would provide a profile of analgesia of rapid onset, yet slow offset. The regimen was evaluated in 58 patients in the recovery ward who were randomly allocated to receive analgesia using pain protocols with either morphine or the mixture. Groups were well matched for age, weight and initial pain scores. The mean (SD) time to patient comfort was 27.6 (20.2) min for the mixture and 41.2 (18.6) min for morphine (p = 0.01). Multiple regression analysis revealed that that initial pain score (p = 0.009) and drug group (p = 0.02), but not age, weight or gender were independent predictors of the time to comfort. Drug group was not a significant predictor of adverse effects.
dc.description.statementofresponsibilityLudbrook, G. L. Macintyre, P. E. Douglas, H. Ong, L. and Upton, R. N.
dc.identifier.citationAnaesthesia, 2001; 56(8):1-7
dc.identifier.doi10.1046/j.1365-2044.2001.02132.x
dc.identifier.issn0003-2409
dc.identifier.issn1365-2044
dc.identifier.orcidLudbrook, G. [0000-0001-6925-4277]
dc.identifier.orcidMacintyre, P. [0000-0002-1569-8056]
dc.identifier.orcidUpton, R. [0000-0001-9996-4886]
dc.identifier.urihttp://hdl.handle.net/2440/14726
dc.language.isoen
dc.publisherBlackwell Science Ltd
dc.source.urihttps://doi.org/10.1046/j.1365-2044.2001.02132.x
dc.subjectPain
dc.subjectpostoperative
dc.subjectAnalgesics: morphine
dc.subjectalfentanil
dc.titleA mixture of alfentanil and morphine for rapid postoperative loading with opioid: theoretical basis and initial clinical investigation
dc.typeJournal article
pubs.publication-statusPublished

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