Lack of impact of donor age on patient survival for renal transplant recipients ≥ 60 years

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dc.contributor.authorLim, W.
dc.contributor.authorDogra, G.
dc.contributor.authorChadban, S.
dc.contributor.authorCampbell, S.
dc.contributor.authorClayton, P.
dc.contributor.authorCohney, S.
dc.contributor.authorRuss, G.
dc.contributor.authorMcDonald, S.
dc.date.issued2012
dc.description.abstractThere has been an increase in the number of older patients on the transplant waiting list and acceptance of older donor kidneys. Although kidneys from older donors have been associated with poorer graft outcomes, whether there is a differential impact of donor age on outcomes in older recipients remains unclear. The aim of this study was to evaluate the effect of donor age on graft and patient survival in renal transplant (RT) recipients ≥60 years. Using the Australia and New Zealand Dialysis and Transplant Registry, outcomes of 1 037 RT recipients ≥60 years between 1995 and 2009 were analyzed. Donor age groups were categorized into 0–20, >20–40, >40–60, and >60 years. Compared with recipients receiving donor kidneys >60 years, those receiving donor kidneys >20–40 years had lower risk of acute rejection (odds ratio 0.46, 95% CI 0.27, 0.79; P < 0.01) and death-censored graft failure (HR 0.37, 95% CI 0.19, 0.72; P < 0.01). There was no association between donor age groups and death. With a corresponding growth in the availability of older donor kidneys and the observed lack of association between donor age and patient survival in RT recipients ≥60 years, preferential allocation of older donor kidneys to RT recipients ≥60 years may not disadvantage the life expectancy of these patients.
dc.description.statementofresponsibilityWai H Lim, Gursharan Dogra, Steve J Chadban, Scott B Campbell, Philip Clayton, Solomon Cohney, Graeme R Russ, and Stephen P McDonald
dc.identifier.citationTransplant International, 2012; 25(4):401-408
dc.identifier.doi10.1111/j.1432-2277.2012.01429.x
dc.identifier.issn0934-0874
dc.identifier.issn1432-2277
dc.identifier.orcidClayton, P. [0000-0001-9190-6753]
dc.identifier.orcidMcDonald, S. [0000-0001-6103-1386]
dc.identifier.urihttp://hdl.handle.net/2440/73279
dc.language.isoen
dc.publisherSpringer-Verlag
dc.rights© 2012 The Authors.
dc.source.urihttps://doi.org/10.1111/j.1432-2277.2012.01429.x
dc.subjectAustralia and New Zealand dialysis and transplant registry
dc.subjectolder donors
dc.subjectolder recipients
dc.subjectsurvival
dc.titleLack of impact of donor age on patient survival for renal transplant recipients ≥ 60 years
dc.title.alternativeLack of impact of donor age on patient survival for renal transplant recipients >/- 60 years
dc.typeJournal article
pubs.publication-statusPublished

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