Isotretinoin-induced skeletal hyperostosis

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dc.contributor.authorGraf, S.W.
dc.contributor.authorWhittle, S.L.
dc.date.issued2014
dc.description.abstractWe describe a case of skeletal hyperostosis in a 29 year old man presenting with non-inflammatory back pain with a past history of isotretinoin therapy for acne. The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. The prevalence and severity of this condition appears to correlate with duration of therapy. Isotretinoin is a well-established treatment for severe acne. It is important for the rheumatologist be aware of this phenomenon when assessing young patients with musculoskeletal symptoms and evidence of radiological abnormalities.
dc.description.statementofresponsibilityScott W Graf, and Samuel L Whittle
dc.identifier.citationSpringerPlus, 2014; 3(1):698-1-698-4
dc.identifier.doi10.1186/2193-1801-3-698
dc.identifier.issn2193-1801
dc.identifier.issn2193-1801
dc.identifier.orcidWhittle, S.L. [0000-0001-7417-7691]
dc.identifier.urihttp://hdl.handle.net/2440/89843
dc.language.isoen
dc.publisherSpringer
dc.rights© 2014 Graf and Whittle; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
dc.source.urihttps://doi.org/10.1186/2193-1801-3-698
dc.titleIsotretinoin-induced skeletal hyperostosis
dc.typeJournal article
pubs.publication-statusPublished

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