Chronic effect of insulin-like growth factor I on renin synthesis, secretion, and renal function in fetal sheep

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dc.contributor.authorMarsh, A.
dc.contributor.authorGibson, K.
dc.contributor.authorWu, J.
dc.contributor.authorOwens, P.
dc.contributor.authorOwens, J.
dc.contributor.authorLumbers, E.
dc.date.issued2001
dc.description.abstractIn the adult, insulin-like growth factor I (IGF-I) increases glomerular filtration rate (GFR) and renal blood flow (RBF) during both acute and chronic treatment. To study its effects on the developing kidney, chronically catheterized fetal sheep (120 ± 1 days gestation) were infused intravenously for up to 10 days with 80 µg/h IGF-I (n = 5) or vehicle (0.1% BSA in saline, n = 6). In contrast to previous acute studies in adult rats and humans, after 4 h of IGF-I fetal GFR and RBF were unchanged. Fractional sodium reabsorption increased (P < 0.05). However, by 4 days, GFR per kilogram had risen by 35 ± 13% (P < 0.05), whereas RBF remained unchanged. Tubular growth and maturation may have occurred, as proximal tubular sodium reabsorption increased by ~35% (P < 0.005). Therefore, despite a marked increase in filtered sodium (~30%, P < 0.05), fractional sodium reabsorption did not change. Although the effects of IGF-I on renal function were delayed, plasma renin activity and concentration were both elevated after 4 h and remained high at 4 days (P < 0.05). Despite this, arterial pressure and heart rate did not change. Kidneys of IGF-I-infused fetuses weighed ~30% more (P = 0.05) and contained ~75% more renin than control fetuses (P < 0.005). Thus, in the fetus, the renal effects of long-term IGF-I infusion are very different from the adult, possibly because IGF-I stimulated kidney growth.
dc.description.statementofresponsibilityAmanda C. Marsh, Karen J. Gibson, June Wu, Phillip C. Owens, Julie A. Owens and Eugenie R. Lumbers
dc.identifier.citationAmerican Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2001; 281(1):R318-R326
dc.identifier.doi10.1152/ajpregu.2001.281.1.r318
dc.identifier.issn0363-6119
dc.identifier.issn1522-1490
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]
dc.identifier.urihttp://hdl.handle.net/2440/11706
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.rightsCopyright © 2001 by the American Physiological Society
dc.source.urihttp://ajpregu.physiology.org/content/281/1/R318
dc.subjectKidney
dc.subjectdevelopment
dc.subjectrenin-angiotensin system
dc.subjectglomerular filtration
dc.titleChronic effect of insulin-like growth factor I on renin synthesis, secretion, and renal function in fetal sheep
dc.typeJournal article
pubs.publication-statusPublished

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