The Protease ADAM17 at the Crossroads of Disease: Revisiting its Significance in Inflammation, Cancer, and Beyond

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dc.contributor.authorSaad, M.I.
dc.contributor.authorJenkins, B.J.
dc.date.issued2024
dc.descriptionFirst published: 04 August 2023
dc.description.abstractThe protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of at least 80 known membrane-tethered proteins, which subsequently modulate several intracellular signaling pathways, and therefore alter cell behavior. Dysregulated expression and/or activation of ADAM17 has been linked to a wide range of autoimmune and inflammatory diseases, cancer and cardiovascular disease. In this review, we provide an overview of the current state of knowledge from preclinical models and clinical data on the diverse pathophysiological roles of ADAM17, and discuss the mechanisms underlying ADAM17-mediated protein shedding and the potential therapeutic implications of targeting ADAM17 in these diseases.
dc.description.statementofresponsibilityMohamed I. Saad, and Brendan J. Jenkins
dc.identifier.citationThe FEBS Journal, 2024; 291(1):10-24
dc.identifier.doi10.1111/febs.16923
dc.identifier.issn1742-464X
dc.identifier.issn1742-4658
dc.identifier.orcidSaad, M.I. [0000-0002-4855-2360]
dc.identifier.orcidJenkins, B.J. [0000-0002-7552-4656]
dc.identifier.urihttps://hdl.handle.net/2440/139422
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1154279
dc.rights© 2023 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of 1 Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1111/febs.16923
dc.subjectADAM17
dc.subjectcancer
dc.subjectcardiovascular diseases
dc.subjectectodomain shedding
dc.subjectinflammation
dc.titleThe Protease ADAM17 at the Crossroads of Disease: Revisiting its Significance in Inflammation, Cancer, and Beyond
dc.typeJournal article
pubs.publication-statusPublished

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