Randomised controlled trial of intravenous maintenance fluids

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dc.contributor.authorYung, M.
dc.contributor.authorKeeley, S.
dc.date.issued2009
dc.description.abstractAim: Traditional paediatric intravenous maintenance fluids are prescribed using hypotonic fluids and the weight-based 4:2:1 formula for administration rate. However, this may cause hyponatraemia in sick and post-operative children. We studied the effect of two types of intravenous maintenance fluid and two administration rates on plasma sodium concentration in intensive care patients. Methods: A Factorial-design, double-blind, randomised controlled trialwas used.We randomised 50 children with normal electrolytes without hypoglycaemia who needed intravenous maintenance fluids for >12 h to 0.9% saline (normal saline) or 4% dextrose and 0.18% saline (dextrose saline), at either the traditional maintenance fluid rate or 2/3 of that rate. The main outcome measure was change in plasma sodium from admission to 12–24 h later. Results: Fifty patients (37 surgical) were enrolled. Plasma sodium fell in all groups: mean fall 2.3 (standard deviation 4.0) mmol/L. Fluid type (P = 0.0063) but not rate (P = 0.12) was significantly associated with fall in plasma sodium. Dextrose saline produced a greater fall in plasma sodium than normal saline: difference 3.0, 95% confidence interval 0.8–5.1 mmol/L. Full maintenance rate produced a greater fall in plasma sodium than restricted rate, but the difference was small and non-significant: 1.6 (-0.7, 3.9) mmol/L. Fluid type, but not rate, remained significant after adjustment for surgical status. One patient, receiving normal saline at restricted rate, developed asymptomatic hypoglycaemia. Conclusion: Sick and post-operative children given dextrose saline at traditional maintenance rates are at risk of hyponatraemia.
dc.description.statementofresponsibilityMichael Yung and Steve Keeley
dc.identifier.citationJournal of Paediatrics and Child Health, 2009; 45(1-2):9-14
dc.identifier.doi10.1111/j.1440-1754.2007.01254.x
dc.identifier.issn1034-4810
dc.identifier.issn1440-1754
dc.identifier.urihttp://hdl.handle.net/2440/49939
dc.language.isoen
dc.provenancePublished Online: 25 Nov 2007
dc.publisherBlackwell Publishing Asia
dc.rightsCopyright © 2007 The Authors
dc.source.urihttps://doi.org/10.1111/j.1440-1754.2007.01254.x
dc.subjectchild
dc.subjectfluid therapy
dc.subjectinfusion
dc.subjectintravenous
dc.titleRandomised controlled trial of intravenous maintenance fluids
dc.typeJournal article
pubs.publication-statusPublished

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