Comparative bioavailability of a microcrystalline theophylline tablet and uncoated aminophylline tablets
Date
1979
Authors
Sansom, L.N.
Milne, R.W.
Cooper, D.
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Journal article
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European Journal of Clinical Pharmacology, 1979; 16(6):417-421
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Abstract
The bioavailability of a rapidly dissolving tablet of theophylline and three brands of standard aminophylline tablets was estimated in a four way cross-over study involving 8 healthy adult volunteers. The relative extent of bioavailability as assessed by the measurement of the total area under the plasma concentration time curves showed no difference between the products (P>0.05). Computed estimates of the rate of drug absorption were similar for all 4 products tested. The results indicate that the rapidly dissolving tablet offers no advantage in respect to rate and extent of absorption over conventional aminophylline tablets.
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Copyright 1979 Springer-Verlag