Daily activities are associated with non-invasive measures of neuroplasticity in older adults

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dc.contributor.authorSmith, A.E.
dc.contributor.authorDumuid, D.
dc.contributor.authorGoldsworthy, M.R.
dc.contributor.authorGraetz, L.
dc.contributor.authorHodyl, N.
dc.contributor.authorThornton, N.L.R.
dc.contributor.authorRidding, M.C.
dc.date.issued2021
dc.description.abstractObjective We aimed to determine the association between daily activities (sleep, sedentary behavior and physical activities) and neuroplasticity in older adults by measuring motor evoked potential amplitudes (MEPs) elicited after a single and spaced continuous theta burst stimulation (cTBS) paradigm, targeting the primary motor cortex. Methods MEPs were recorded from the right first dorsal interosseous muscle of 34 older adults (66.9 ± 4.5 years) by delivering single-pulse TMS before, between and at 0, 10, 20, 40 and 60 min after the application of spaced-cTBS separated by 10 min. Habitual activity was assessed by accelerometry for 24 h/day over 7-days. Multiple linear regression models determined if the time-use composition (sleep, sedentary behavior and physical activities) was associated with neuroplasticity response. Results More physical activity at the equal expense of sleep and sedentary behaviors was associated with greater motor cortical neuroplasticity. Associations appeared to be driven by more time spent in light- but not moderate-to-vigorous- physical activities. Conclusions Engaging in light physical activity at the expense of sleep and sedentary behavior was associated with greater LTD-like motor cortex neuroplasticity (as measured with cTBS) in older adults. Significance These findings suggest the promotion of physical activity among older adults to support brain neuroplasticity.
dc.description.statementofresponsibilityAshleigh E.Smith, Dorothea Dumuid, Mitchell R.Goldsworthy, Lynton Graetz, Nicolette Hodyl, Nicollette L.R.Thornton, Michael C.Ridding
dc.identifier.citationClinical Neurophysiology, 2021; 132(4):984-992
dc.identifier.doi10.1016/j.clinph.2021.01.016
dc.identifier.issn1388-2457
dc.identifier.issn1872-8952
dc.identifier.orcidGoldsworthy, M.R. [0000-0002-0688-9475]
dc.identifier.orcidGraetz, L. [0000-0001-9163-3150]
dc.identifier.orcidHodyl, N. [0000-0003-2025-5310]
dc.identifier.urihttp://hdl.handle.net/2440/130458
dc.language.isoen
dc.publisherElsevier BV
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1097397
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1102272
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1162166
dc.rights© 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.clinph.2021.01.016
dc.subjectTranscranial magnetic stimulation (TMS); Compositional data analysis (CoDA); Neuroplasticity; Physical activity (PA); Sleep Sedentary behavior (SB)
dc.titleDaily activities are associated with non-invasive measures of neuroplasticity in older adults
dc.typeJournal article
pubs.publication-statusPublished

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