The splice of life: Alternative splicing and neurological disease

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dc.contributor.authorDredge, B.
dc.contributor.authorPolydorides, A.
dc.contributor.authorDarnell, R.
dc.date.issued2001
dc.description.abstractSplicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has contributed to our understanding of disease pathogenesis in some cases. Neuron-specific proteins involved in RNA splicing and metabolism are also affected in several neurological disorders. These findings have begun to bridge what we know about the mechanisms regulating neuron-specific splicing and our understanding of neural function and disease.
dc.description.statementofresponsibilityB. Kate Dredge, Alexandros D. Polydorides and Robert B.Darnell
dc.identifier.citationNature Reviews Neuroscience, 2001; 2(1):43-50
dc.identifier.doi10.1038/35049061
dc.identifier.issn1471-003X
dc.identifier.issn1471-0048
dc.identifier.orcidDredge, B. [0000-0002-6103-5165]
dc.identifier.urihttp://hdl.handle.net/2440/34840
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights© 2001 Nature Publishing Group
dc.source.urihttps://doi.org/10.1038/35049061
dc.subjectBrain
dc.subjectNeurons
dc.subjectAnimals
dc.subjectHumans
dc.subjectNervous System Diseases
dc.subjectRNA-Binding Proteins
dc.subjectRNA Precursors
dc.subjectAlternative Splicing
dc.titleThe splice of life: Alternative splicing and neurological disease
dc.typeJournal article
pubs.publication-statusPublished

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