The impact of maternal asthma on the fetal lung: Outcomes, mechanisms and interventions

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dc.contributor.authorRobinson, J.L.
dc.contributor.authorGatford, K.L.
dc.contributor.authorClifton, V.L.
dc.contributor.authorMorrison, J.L.
dc.contributor.authorStark, M.J.
dc.date.issued2024
dc.descriptionAvailable online 23 December 2023
dc.description.abstractMaternal asthma affects up to 17% of pregnancies and is associated with adverse infant, childhood, and adult respiratory outcomes, including increased risks of neonatal respiratory distress syndrome, childhood wheeze and asthma. In addition to genetics, these poor outcomes are likely due to the mediating influence of maternal asthma on the in-utero environment, altering fetal lung and immune development and predisposing the offspring to later lung disease. Maternal asthma may impair glucocorticoid signalling in the fetus, a process critical for lung maturation, and increase fetal exposure to proinflammatory cytokines. Therefore, interventions to control maternal asthma, increase glucocorticoid signalling in the fetal lung, or Vitamin A, C, and D supplementation to improve alveologenesis and surfactant production may be beneficial for later lung function. This review highlights potential mechanisms underlying maternal asthma and offspring respiratory morbidities and describes how pregnancy interventions can promote optimal fetal lung development in babies of asthmatic mothers.
dc.description.statementofresponsibilityJoshua L. Robinson, Kathryn L. Gatford, Vicki L. Clifton, Janna L. Morrison, Michael J. Stark
dc.identifier.citationPaediatric Respiratory Reviews, 2024; 51:38-45
dc.identifier.doi10.1016/j.prrv.2023.12.004
dc.identifier.issn1526-0542
dc.identifier.issn1526-0550
dc.identifier.orcidRobinson, J.L. [0000-0001-5267-1496]
dc.identifier.orcidGatford, K.L. [0000-0002-2823-3004]
dc.identifier.orcidClifton, V.L. [0000-0002-4892-6748]
dc.identifier.orcidStark, M.J. [0000-0003-1835-8679]
dc.identifier.urihttps://hdl.handle.net/2440/140400
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/arc/FT170100431
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1136100
dc.rights© 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttp://dx.doi.org/10.1016/j.prrv.2023.12.004
dc.subjectFetus
dc.subjectLung development
dc.subjectMaternal asthma
dc.subjectPregnancy
dc.titleThe impact of maternal asthma on the fetal lung: Outcomes, mechanisms and interventions
dc.typeJournal article
pubs.publication-statusPublished

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