GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer
Date
2016
Authors
Chen, M.M.
O'Mara, T.A.
Thompson, D.J.
Painter, J.N.
Attia, J.
Black, A.
Brinton, L.
Chanock, S.
Chen, C.
Cheng, T.H.
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Journal article
Citation
Human Molecular Genetics, 2016; 25(12):2612-2620
Statement of Responsibility
Maxine M. Chen, Tracy A. O'Mara, Deborah J. Thompson, Jodie N. Painter, John Attia … Joanne Young … et al. (The Australian National Endometrial Cancer Study Group and National Study Of Endometrial Cancer Genetics Group)
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Abstract
Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
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© The Author 2016. Published by Oxford University Press. All rights reserved.