A novel virus detected in papillomas and carcinomas of the endangered western barred bandicoot (Perameles bougainville) exhibits genomic features of both the Papillomaviridae and Polyomaviridae

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dc.contributor.authorWoolford, L.
dc.contributor.authorRector, A.
dc.contributor.authorVan Ranst, M.
dc.contributor.authorDucki, A.
dc.contributor.authorBennett, M.
dc.contributor.authorNicholls, P.
dc.contributor.authorWarren, K.
dc.contributor.authorSwan, R.
dc.contributor.authorWilcox, G.
dc.contributor.authorO'Hara, A.
dc.date.issued2007
dc.description.abstractConservation efforts to prevent the extinction of the endangered western barred bandicoot (Perameles bougainville) are currently hindered by a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome observed in captive and wild populations. In this study, we detected a novel virus, designated the bandicoot papillomatosis carcinomatosis virus type 1 (BPCV1), in lesional tissue from affected western barred bandicoots using multiply primed rolling-circle amplification and PCR with the cutaneotropic papillomavirus primer pairs FAP59/FAP64 and AR-L1F8/AR-L1R9. Sequencing of the BPCV1 genome revealed a novel prototype virus exhibiting genomic properties of both the Papillomaviridae and the Polyomaviridae. Papillomaviral properties included a large genome size (~7.3 kb) and the presence of open reading frames (ORFs) encoding canonical L1 and L2 structural proteins. The genomic organization in which structural and nonstructural proteins were encoded on different strands of the double-stranded genome and the presence of ORFs encoding the nonstructural proteins large T and small t antigens were, on the other hand, typical polyomaviral features. BPCV1 may represent the first member of a novel virus family, descended from a common ancestor of the papillomaviruses and polyomaviruses recognized today. Alternatively, it may represent the product of ancient recombination between members of these two virus families. The discovery of this virus could have implications for the current taxonomic classification of Papillomaviridae and Polyomaviridae and can provide further insight into the evolution of these ancient virus families.
dc.description.statementofresponsibilityLucy Woolford, Annabel Rector, Marc Van Ranst, Andrea Ducki, Mark D. Bennett, Philip K. Nicholls, Kristin S. Warren, Ralph A. Swan, Graham E. Wilcox, and Amanda J. O’Hara
dc.identifier.citationJournal of Virology, 2007; 81(24):13280-13290
dc.identifier.doi10.1128/JVI.01662-07
dc.identifier.issn0022-538X
dc.identifier.issn1098-5514
dc.identifier.orcidWoolford, L. [0000-0001-7271-2937]
dc.identifier.urihttp://hdl.handle.net/2440/66447
dc.language.isoen
dc.publisherAmer Soc Microbiology
dc.rightsCopyright © 2007, American Society for Microbiology. All Rights Reserved.
dc.source.urihttps://doi.org/10.1128/jvi.01662-07
dc.subjectAnimals
dc.subjectMarsupialia
dc.subjectDNA Viruses
dc.subjectPapillomaviridae
dc.subjectPolyomaviridae
dc.subjectDNA Virus Infections
dc.subjectCarcinoma
dc.subjectPapilloma
dc.subjectViral Proteins
dc.subjectDNA, Viral
dc.subjectAntigens, Viral, Tumor
dc.subjectPolymerase Chain Reaction
dc.subjectSequence Analysis, DNA
dc.subjectConservation of Natural Resources
dc.subjectEvolution, Molecular
dc.subjectRecombination, Genetic
dc.subjectGenome, Viral
dc.subjectOpen Reading Frames
dc.subjectMolecular Sequence Data
dc.titleA novel virus detected in papillomas and carcinomas of the endangered western barred bandicoot (Perameles bougainville) exhibits genomic features of both the Papillomaviridae and Polyomaviridae
dc.typeJournal article
pubs.publication-statusPublished

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