Global, regional and national burden of cancers attributable to high fasting plasma glucose in 204 countries and territories, 1990-2019
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Date
2022
Authors
Safiri, S.
Nejadghaderi, S.A.
Karamzad, N.
Kaufman, J.S.
Carson Chahhoud, K.
Bragazzi, N.L.
Sullman, M.J.M.
Beyranvand, M.R.
Mansournia, M.A.
Almasi Hashiani, A.
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Frontiers in Endocrinology, 2022; 13(879890):1-12
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Background: To report the burden of cancers attributable to high fasting plasma glucose (HFPG) by sex, age, location, cancer type and Socio-demographic Index (SDI) over the period 1990 to 2019 for 204 countries and territories.
Methods: Using the Comparative Risk Assessment approach of Global Burden of Disease (GBD) study 2019, the burden of cancers attributable to HFPG was reported in 1990 and 2019.
Results: Globally, in 2019 there were an estimated 419.3 thousand cancer deaths (95% UI: 115.7 to 848.5) and 8.6 million cancer DALYs (2.4 to 17.6) attributable to HFPG. By sex, 4.6 (1.1 to 9.9) and 4.0 (1.1 to 8.4) million global cancer DALYs were attributable to HFPG in men and women, respectively. The global age-standardized death and DALY rates of cancers attributable to HFPG (per 100,000) have increased by 27.8% (20.5 to 38.7%) and 24.5% (16.4 to 35.6%), respectively, since 1990. High-income North America (9.5 [2.7 to 18.8]) and Eastern Sub-Saharan Africa (2.0 [0.5 to 4.2]) had the highest and lowest regional age-standardized death rates, respectively, for cancers attributable to HFPG. In 2019, the global number of attributable cancer DALYs were highest in 65-69 age group. Moreover, there was an overall positive association between SDI and the regional age-standardized DALY rate for HFPG-attributable cancers.
Conclusions: HFPG was associated with more burden in 2019. Preventive programs for diabetes and screening of individuals with diabetes for cancers, especially in older males living in developed countries, are required to arrest the large increases in HFPG-attributable cancers.
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Data source: Supplementary Material, https://www.frontiersin.org/articles/10.3389/fendo.2022.879890/full#supplementary-material
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Copyright 2022 Safiri, Nejadghaderi, Karamzad, Kaufman, Carson-Chahhoud, Bragazzi, Sullman, Beyranvand, Mansournia, Almasi-Hashiani, Collins and Kolahi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.