Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces: Via an epoxide plasma polymer interlayer
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(Published version)
Date
2017
Authors
Michl, T.
Giles, C.
Cross, A.
Griesser, H.
Coad, B.
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RSC Advances, 2017; 7(44):27678-27681
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Thomas D. Michl, Carla Giles, Alasdair T. Cross, Hans J. Griesser and Bryan R. Coad
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Abstract
We report a facile, one-step, aqueous surface bioconjugation approach for producing an antifungal surface coating that prevents the formation of fungal biofilms. By direct reaction between surface epoxide groups and amine groups on caspofungin, it avoids the use of secondary chemicals. The coating withstands washing with detergent and reduces the growth of the fungal pathogens Candida albicans by log 6 and Candida glabrata by log 3. Importantly, we show that surface adsorption of albumin does not inhibit the activity of this antifungal coating.
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Data source: Supplementary information, https://doi.org/10.1039/c7ra03897f
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This journal is © The Royal Society of Chemistry 2017. Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.