Deficiency of 6B11+invariant NK T-cells in celiac disease

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dc.contributor.authorGrose, R.
dc.contributor.authorThompson, F.
dc.contributor.authorCummins, A.
dc.date.issued2008
dc.descriptionThe definitive version can be found at www.springerlink.com
dc.description.abstractImmunoregulatory NK T-cells are deficient in certain autoimmune diseases. The purpose of this study was to investigate any deficiency of immunoregulatory NK T-cells in celiac disease. NK T-cells were identified by flow cytometry with 6B11 and Vα24 markers in blood from 18 normal and 12 celiac subjects. Blood mononuclear cells were stimulated with anti-CD3/CD28 antibodies and intracellular cytokines assessed at 4 h in seven normal and eight celiac subjects. Vα24/GAPDH mRNA was quantitated in duodenal biopsies by real time PCR in 17 control and 13 celiac subjects. NK T-cells in celiac subjects were reduced to 30% of those in normal subjects. Intracellular IL-4, IL-10 and IL-13 increased significantly by 33–41% in normal subjects, but did not change in celiac subjects. Vα24/GAPDH mRNA from celiac subjects was reduced to 5% of levels in control subjects. We conclude that immunoregulatory NK T-cells are deficient in celiac disease.
dc.description.statementofresponsibilityRandall H. Grose, Fiona M. Thompson and Adrian G. Cummins
dc.identifier.citationDigestive Diseases and Sciences, 2008; 53(7):1846-1851
dc.identifier.doi10.1007/s10620-007-0093-x
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.orcidCummins, A. [0000-0003-3115-9498]
dc.identifier.urihttp://hdl.handle.net/2440/46403
dc.language.isoen
dc.publisherKluwer Academic/Plenum Publ
dc.source.urihttps://doi.org/10.1007/s10620-007-0093-x
dc.subjectCeliac disease
dc.subjectImmunoregulatory
dc.subjectNK T-cells
dc.titleDeficiency of 6B11+invariant NK T-cells in celiac disease
dc.typeJournal article
pubs.publication-statusPublished

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