Malaria parasite clearance: what are we really measuring?

Khoury, D.S.; Zaloumis, S.G.; Grigg, M.J.; Haque, A.; Davenport, M.P.; Cromer, D.; Rebelo, M.; Cao, P.; McCaw, J.M.; Simpson, J.A.; Flegg, J.A.; Wilson, D.W.; Anstey, N.M.; McCarthy, J.S.

doi:10.1016/j.pt.2020.02.005

Malaria parasite clearance: what are we really measuring?

Date

2020

Authors

Khoury, D.S.

Zaloumis, S.G.

Grigg, M.J.

Haque, A.

Davenport, M.P.

Cromer, D.

Rebelo, M.

Cao, P.

McCaw, J.M.

Simpson, J.A.

Type:

Journal article

Citation

Trends in Parasitology, 2020; 36(5):413-426

Statement of Responsibility

David S.Khoury, Sophie G.Zaloumis, Matthew J.Grigg, Ashraful Haque, Miles P.Davenport, The Interdisciplinary Approaches to Malaria Consortium

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10.1016/j.pt.2020.02.005

Abstract

Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires large clinical trials and thus we have identified proxy measures of drug efficacy such as the parasite clearance curve. This is often assumed to measure the rate of drug activity against parasites and is used to predict optimal treatment regimens required to completely clear a blood-stage infection. We discuss evidence that the clearance curve is not measuring the rate of drug killing. This has major implications for how we assess optimal treatment regimens, as well as how we prioritise new drugs in the drug development pipeline.

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https://doi.org/10.1016/j.pt.2020.02.005

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https://hdl.handle.net/2440/134069

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Malaria parasite clearance: what are we really measuring?

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