Cost-effectiveness of closed incision negative pressure wound therapy in preventing surgical site infection among obese women giving birth by caesarean section: An economic evaluation (DRESSING trial)

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dc.contributor.authorWhitty, J.A.
dc.contributor.authorWagner, A.P.
dc.contributor.authorKang, E.
dc.contributor.authorEllwood, D.
dc.contributor.authorChaboyer, W.
dc.contributor.authorKumar, S.
dc.contributor.authorClifton, V.L.
dc.contributor.authorThalib, L.
dc.contributor.authorGillespie, B.M.
dc.date.issued2023
dc.descriptionFirst published: 18 May 2023
dc.description.abstractBackground: There is growing evidence regarding the potential of closed incision negative pressure wound therapy (ci-NPWT) to prevent surgical site infections (SSIs) in healing wounds by primary closure following a caesarean section (CS). Aim: To assess the cost-effectiveness of ci-NPWT compared to standard dressings for prevention of SSI in obese women giving birth by CS. Materials and Methods: Cost-effectiveness and cost-utility analyses from a health service perspective were undertaken alongside a multicentre pragmatic randomised controlled trial, which recruited women with a pre-pregnancy body mass index ≥30 kg/m2 giving birth by elective/semi-urgent CS who received ci-NPWT (n = 1017) or standard dressings (n = 1018). Resource use and health-related quality of life (SF-12v2) collected during admission and for four weeks post-discharge were used to derive costs and quality-adjusted life years (QALYs). Results: ci-NPWT was associated with AUD$162 (95%CI −$170 to $494) higher cost per person and an additional $12 849 (95%CI −$62 138 to $133 378) per SSI avoided. There was no detectable difference in QALYs between groups; however, there are high levels of uncertainty around both cost and QALY estimates. There is a 20% likelihood that ci-NPWT would be considered cost-effective at a willingness-to- pay threshold of $50 000 per QALY. Per protocol and complete case analyses gave similar results, suggesting that findings are robust to protocol deviators and adjustments for missing data. Conclusions: ci-NPWT for the prevention of SSI in obese women undergoing CS is unlikely to be cost-effective in terms of health service resources and is currently unjustified for routine use for this purpose.
dc.description.statementofresponsibilityJennifer A. Whitty, Adam P. Wagner, Evelyn Kang, David Ellwood, Wendy Chaboyer, Sailesh Kumar, Vicki L. Clifton, Lukman Thalib and Brigid M. Gillespie
dc.identifier.citationAustralian and New Zealand Journal of Obstetrics and Gynaecology, 2023; 63(5):673-680
dc.identifier.doi10.1111/ajo.13677
dc.identifier.issn0004-8666
dc.identifier.issn1479-828X
dc.identifier.orcidClifton, V.L. [0000-0002-4892-6748]
dc.identifier.urihttps://hdl.handle.net/2440/138549
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1081026
dc.rights© 2023 The Authors. Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists.ently unjustified for routine use for this purpose. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1111/ajo.13677
dc.subjectcaesarean section
dc.subjectcost-effectiveness
dc.subjecteconomic evaluation
dc.subjectnegative pressure wound therapy
dc.subjectsurgical site infection
dc.titleCost-effectiveness of closed incision negative pressure wound therapy in preventing surgical site infection among obese women giving birth by caesarean section: An economic evaluation (DRESSING trial)
dc.typeJournal article
pubs.publication-statusPublished

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