Intramyocardial navigation and mapping for stem cell delivery

Simple item page
dc.contributor.authorPsaltis, P.
dc.contributor.authorZannettino, A.
dc.contributor.authorGronthos, S.
dc.contributor.authorWorthley, S.
dc.date.issued2010
dc.description.abstractMethod for delivery remains a central component of stem cell-based cardiovascular research. Comparative studies have demonstrated the advantages of administering cell therapy directly into the myocardium, as distinct from infusing cells into the systemic or coronary vasculature. Intramyocardial delivery can be achieved either transepicardially or transendocardially. The latter involves percutaneous, femoral arterial access and the retrograde passage of specially designed injection catheters into the left ventricle, making it less invasive and more relevant to wider clinical practice. Imaging-based navigation plays an important role in guiding catheter manipulation and directing endomyocardial injections. The most established strategy for three-dimensional, intracardiac navigation is currently endoventricular, electromechanical mapping, which offers superior spatial orientation compared to simple x-ray fluoroscopy. Its provision of point-by-point, electrophysiologic and motion data also allows characterization of regional myocardial viability, perfusion, and function, especially in the setting of ischemic heart disease. Integrating the mapping catheter with an injection port enables this diagnostic information to facilitate the targeting of intramyocardial stem cell delivery. This review discusses the diagnostic accuracy and expanding therapeutic application of electromechanical navigation in cell-based research and describes exciting developments which will improve the technology’s sensing capabilities, image registration, and delivery precision in the near future.
dc.description.statementofresponsibilityPeter J. Psaltis, Andrew C. W. Zannettino, Stan Gronthos and Stephen G. Worthley
dc.identifier.citationJournal of Cardiovascular Translational Research, 2010; 3(2 Sp Iss):135-146
dc.identifier.doi10.1007/s12265-009-9138-1
dc.identifier.issn1937-5387
dc.identifier.issn1937-5395
dc.identifier.orcidPsaltis, P. [0000-0003-0222-5468]
dc.identifier.orcidZannettino, A. [0000-0002-6646-6167]
dc.identifier.orcidGronthos, S. [0000-0002-6225-3084]
dc.identifier.urihttp://hdl.handle.net/2440/57953
dc.language.isoen
dc.publisherSpringer New York LLC
dc.rights© Springer Science + Business Media, LLC 2009
dc.source.urihttps://doi.org/10.1007/s12265-009-9138-1
dc.subjectCardiac Navigation
dc.subjectElectromechanical Mapping
dc.subjectIntramyocardial Delivery
dc.subjectMyocardial Viability
dc.subjectNOGA
dc.subjectStem Cell Therapy
dc.titleIntramyocardial navigation and mapping for stem cell delivery
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications