Exploring lipid affinities of persistent organic pollutants and MeO-PBDEs in blubber of marine mammals

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dc.contributor.authorWeijs, L.
dc.contributor.authorCovaci, A.
dc.contributor.authorCarroll, A.
dc.contributor.authorKemper, C.
dc.contributor.authorMelvin, S.
dc.date.issued2022
dc.description.abstractAlthough lipophilic compounds have been the focus of numerous studies in marine mammals, their association with lipids is widely accepted, but rarely scrutinized. This pilot study aimed to investigate potential relationships between individual lipids from different lipid classes identified through a non-targeted Nuclear Magnetic Resonance (NMR) based lipidomics approach and legacy POPs in the blubber of long-finned pilot whales, sperm whales, common bottlenose dolphins, and Indo-Pacific bottlenose dolphins. Concentrations of selected POPs such as HCB and HCHs in sperm whales from Tasmania were found to differ from those in long-finned pilot whales and common bottlenose dolphins from the same location. Profiles of NMR spectra measured in blubber of sperm whales were also distinctly different compared to the pilot whales and common bottlenose dolphins. Two groups of Indo-Pacific bottlenose dolphins from South Australia that were 20 years apart showed highly comparable profiles of NMR signals despite having higher concentrations of several POP classes in the more recent group. More specific correlations were investigated between selected POPs (n = 12) and all detected NMR signals (n = 63) in all species. Outcomes were species-specific, but difficult to interpret due to the lack of available literature for marine mammals and the small sample sizes per species. Because of the key role of lipids in the bioaccumulation of POPs and in the incidence of diseases, more attention should be given to the identification and characterization of lipid species in future toxicological studies. However, future studies should focus on one marine mammal species to increase sample sizes and limit the number of confounding factors, such as diet, that can influence POP and lipid levels and profiles.
dc.description.statementofresponsibilityLiesbeth Weijs, Adrian Covaci, Anthony Carroll, Catherine Kemper, Steve Melvin
dc.identifier.citationChemosphere, 2022; 308(Pt 3):136448-
dc.identifier.doi10.1016/j.chemosphere.2022.136448
dc.identifier.issn0045-6535
dc.identifier.issn1879-1298
dc.identifier.urihttps://hdl.handle.net/2440/137132
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.granthttp://purl.org/au-research/grants/arc/DE160100468
dc.rights© 2022 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.chemosphere.2022.136448
dc.subjectLipidomics; Marine mammals; Blubber; Lipophilic; POPs
dc.subject.meshAdipose Tissue
dc.subject.meshAnimals
dc.subject.meshHexachlorobenzene
dc.subject.meshLipids
dc.subject.meshWater Pollutants, Chemical
dc.subject.meshPilot Projects
dc.subject.meshEnvironmental Monitoring
dc.subject.meshFin Whale
dc.subject.meshSperm Whale
dc.subject.meshBottle-Nosed Dolphin
dc.subject.meshWhales, Pilot
dc.subject.meshHalogenated Diphenyl Ethers
dc.subject.meshCaniformia
dc.subject.meshPersistent Organic Pollutants
dc.titleExploring lipid affinities of persistent organic pollutants and MeO-PBDEs in blubber of marine mammals
dc.typeJournal article
pubs.publication-statusPublished

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