Differential effects of light wavelength in phase advancing the melatonin rhythm

Simple item page
dc.contributor.authorWright, H.
dc.contributor.authorLack, L.
dc.contributor.authorKennaway, D.
dc.date.issued2004
dc.descriptionThe definitive version is available at www.blackwell-synergy.com
dc.description.abstractShorter wavelength light has been shown to be more effective than longer wavelengths in suppressing nocturnal melatonin and phase delaying the melatonin rhythm. In the present study, different wavelengths of light were evaluated for their capacity to phase advance the saliva melatonin rhythm. Two long wavelengths, 595 nm (amber) and 660 nm (red) and three shorter wavelengths, 470 nm (blue), 497 nm (blue/green), and 525 nm (green) were compared with a no-light control condition. Light was administered via a portable light source comprising two light-emitting diodes per eye, with the irradiance of each diode set at 65 μW/cm2. Forty-two volunteers participated in up to six conditions resulting in 15 per condition. For the active light conditions, a 2-hr light pulse was administered from 06:00 hr on two consecutive mornings. Half-hourly saliva samples were collected on the evening prior to the first light pulse and the evening following the second light pulse. The time of melatonin onset was calculated for each night and the difference was calculated as a measure of phase advance. The shorter wavelengths of 470, 495 and 525 nm showed the greatest melatonin onset advances ranging from approximately 40–65 min while the longer wavelengths produced no significant phase advance. These results strengthen earlier findings that the human circadian system is more sensitive to the short wavelengths of light than the longer wavelengths.
dc.description.statementofresponsibilityHelen R. Wright, Leon C. Lack and David J. Kennaway
dc.identifier.citationJournal of Pineal Research, 2004; 36(2):140-144
dc.identifier.doi10.1046/j.1600-079X.2003.00108.x
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.orcidKennaway, D. [0000-0002-5864-3514]
dc.identifier.urihttp://hdl.handle.net/2440/8316
dc.language.isoen
dc.publisherBlackwell Munksgaard
dc.source.urihttps://doi.org/10.1046/j.1600-079x.2003.00108.x
dc.subjectSaliva
dc.subjectHumans
dc.subjectMelatonin
dc.subjectLighting
dc.subjectCircadian Rhythm
dc.subjectDose-Response Relationship, Drug
dc.subjectTime Factors
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.titleDifferential effects of light wavelength in phase advancing the melatonin rhythm
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Obstetrics and Gynaecology publications