A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease

Date

2013

Authors

Jones, S.
Neilsen, P.
Siew, L.
Callen, D.
Goldfarb, N.
Dunn, B.
Abell, A.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

ChemMedChem: chemistry enabling drug discovery, 2013; 8(12):1918-1921

Statement of Responsibility

Seth A. Jones, Paul M. Neilsen, Limei Siew, David F. Callen, Nathan E. Goldfarb, Ben M. Dunn, and Andrew D. Abell

Conference Name

DOI

10.1002/cmdc.201300387

Abstract

Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P2 , and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease.

School/Discipline

Dissertation Note

Provenance

Description

Article first published online: 15 OCT 2013

Access Status

Rights

© 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

License

Grant ID

ARC

Published Version

https://doi.org/10.1002/cmdc.201300387

Call number

Persistent link to this record

http://hdl.handle.net/2440/82767