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Novel technical developments in mass spectrometry imaging in 2020: A mini review

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dc.contributor.authorDilmetz, B.A.
dc.contributor.authorLee, Y.R.
dc.contributor.authorCondina, M.R.
dc.contributor.authorBriggs, M.
dc.contributor.authorYoung, C.
dc.contributor.authorDesire, C.T.
dc.contributor.authorKlingler-Hoffmann, M.
dc.contributor.authorHoffmann, P.
dc.date.issued2021
dc.description.abstractThe applicability of mass spectrometry imaging (MSI) has exponentially increased with the improvement of sample preparation, instrumentation (spatial resolution) and data analysis. The number of MSI publications listed in PubMed continues to grow with 378 published articles in 2020-2021. Initially, MSI was just sensitive enough to identify molecular features correlating with distinct tissue regions, similar to the resolution achieved by visual inspection after standard immunohistochemical staining. Although the spatial resolution was limited compared with other imaging modalities, the molecular intensity mapping added a new exciting capability. Over the past decade, significant improvements in every step of the workflow and most importantly in instrumentation were made, which now enables the molecular analysis at a cellular and even subcellular level. Here, we summarize the latest developments in MSI, with a focus on the latest approaches for tissue-based imaging described in 2020.
dc.identifier.citationAnalytical Science Advances, 2021; 2(3-4):225-237
dc.identifier.doi10.1002/ansa.202000176
dc.identifier.issn2628-5452
dc.identifier.issn2628-5452
dc.identifier.orcidBriggs, M. [0000-0002-6601-2552]
dc.identifier.orcidKlingler-Hoffmann, M. [0000-0003-2165-7813]
dc.identifier.orcidHoffmann, P. [0000-0002-6573-983X]
dc.identifier.urihttps://hdl.handle.net/11541.2/26454
dc.language.isoen
dc.publisherWiley
dc.rightsCopyright 2021 The Authors. Analytical Science Advances published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1002/ansa.202000176
dc.subjectMALDI
dc.subjectworkflows
dc.subjectmass spectrometry imaging
dc.titleNovel technical developments in mass spectrometry imaging in 2020: A mini review
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12236823640001831 13236823630001831 ansa.202000176 (1)
ror.mmsid9916583840501831

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