Investigating the demographic history of Japan using ancient oral microbiota

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dc.contributor.authorEisenhofer Philipona, R.
dc.contributor.authorKanzawa-Kiriyama, H.
dc.contributor.authorShinoda, K.I.
dc.contributor.authorWeyrich, L.S.
dc.date.issued2020
dc.description.abstractWhile microbial communities in the human body (microbiota) are now commonly associated with health and disease in industrialised populations, we know very little about how these communities co-evolved and changed with humans throughout history and deep prehistory. We can now examine these communities by sequencing ancient DNA preserved within calcified dental plaque (calculus), providing insights into the origins of disease and their links to human history. Here, we examine ancient DNA preserved within dental calculus samples and their associations with two major cultural periods in Japan: the Jomon period hunter–gatherers approximately 3000 years before present (BP) and the Edo period agriculturalists 400–150 BP. We investigate how human oral microbiomes have changed in Japan through time and explore the presence of microorganisms associated with oral diseases (e.g. periodontal disease, dental caries) in ancient Japanese populations. Finally, we explore oral microbial strain diversity and its potential links to ancient demography in ancient Japan by performing phylogenomic analysis of a widely conserved oral species—Anaerolineaceae oral taxon 439. This research represents, to our knowledge, the first study of ancient oral microbiomes from Japan and demonstrates that the analysis of ancient dental calculus can provide key information about the origin of non-infectious disease and its deep roots with human demography. This article is part of the theme issue ‘Insights into health and disease from ancient biomolecules’.
dc.description.statementofresponsibilityRaphael Eisenhofer, Hideaki Kanzawa-Kiriyama, Ken-ichi Shinoda and Laura S. Weyrich
dc.identifier.citationPhilosophical Transactions of the Royal Society B: Biological Sciences, 2020; 375(1812):20190578-1-20190578-11
dc.identifier.doi10.1098/rstb.2019.0578
dc.identifier.issn0962-8436
dc.identifier.issn1471-2970
dc.identifier.orcidEisenhofer Philipona, R. [0000-0002-3843-0749]
dc.identifier.urihttps://hdl.handle.net/2440/133153
dc.language.isoen
dc.publisherThe Royal Society Publishing
dc.relation.granthttp://purl.org/au-research/grants/arc/CE170100015
dc.relation.granthttp://purl.org/au-research/grants/arc/DE150101574
dc.rights© 2020 The Author(s) Published by the Royal Society. All rights reserved.
dc.source.urihttps://doi.org/10.1098/rstb.2019.0578
dc.subjectJapan; microbiome; ancient DNA; phylogenomics; palaeomicrobiology
dc.subject.meshMouth
dc.subject.meshHumans
dc.subject.meshChloroflexi
dc.subject.meshPeriodontal Diseases
dc.subject.meshDental Caries
dc.subject.meshDemography
dc.subject.meshPopulation Dynamics
dc.subject.meshPhylogeny
dc.subject.meshGenome, Bacterial
dc.subject.meshHistory, Ancient
dc.subject.meshHistory, 17th Century
dc.subject.meshHistory, 18th Century
dc.subject.meshHistory, 19th Century
dc.subject.meshJapan
dc.subject.meshMicrobiota
dc.titleInvestigating the demographic history of Japan using ancient oral microbiota
dc.typeJournal article
pubs.publication-statusPublished

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